Journal of Advances in Medical and Biomedical Research
Journal of Advances in Medical and Biomedical Research
J Adv Med Biomed Res
Medical Sciences
http://journal.zums.ac.ir
52
journal52
1606-9366
2676-6264
10.30699/jambr
en
jalali
1397
2
1
gregorian
2018
5
1
26
115
online
1
fulltext
fa
بررسی بیوانفورماتیکی میانکنش بین میکرو RNAها با ژنهای دخیل در عود مجدد سرطان پستان درمان شده با تاموکسیفن
The Bioinformatics Study of the Interactions between MicroRNAs and Genes Involved in Relapse of breast Cancer Treated with Tamoxifen
کارآزمایی بالینی
Clinical Trials
<p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span style="color:#008080;"><strong><em>Background and Objective</em></strong>:</span> Tamoxifen is the most commonly used treatment for the patients with breast cancer called ER +, which prevents the expression of genes that are effective in the growth and proliferation of cancer cells by estrogen. Resistant to Tamoxifen is a major clinical problem in breast cancer treatment. In recent studies, the role of microRNAs in tamoxifen resistance has been raised through the influence of regulation of cell cycle control genes. Throughout this study, the interactions of microRNAs with genes involved in tamoxifen resistance were investigated.<br>
<span style="color:#008080;"><strong><em>Materials and Methods</em></strong>:</span> By comparing the gene expression data in samples of patients sensitive and resistant to Tamoxifen from the GEO database and searching in the database of articles, genes and microRNAs with significant expression variations were determined. Then, by examining the correlation between the expression of genes and microRNAs and bioinformatics by mirwalk software, the interconnection network between the genes and microRNAs was drawn.<br>
<span style="color:#008080;"><strong><em>Results</em></strong>:</span> The results showed that 21 genes and 62 microRNAs altered in Tamoxifen resistant specimens. With miR342-3P/5P targeting the HOXB13, PRM2, and KLK3 genes, and MiR-520h and miR-582-5p microRNAs, targeting 5 reduced expression genes, can lead to recurrence of breast cancer.<br>
<span style="color:#008080;"><strong><em>Conclusion</em></strong><em>:</em></span> The regulatory network mapped out between a set of genes and microRNAs that are potentially involved in the recurrence of breast cancer treated with Tamoxifen could clarify the role of the microRNAs in the recurrence of breast cancer.</span></span></p>
Breast cancer, Tamoxifen, Relapse, Interconnecting network, MicroRNA, Bioinformatics
22
34
http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1069&slc_lang=fa&sid=1
Shahin
Ramazi
شهین
رمازی
shahinramazi@yahoo.com