en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><strong><span style="background-color:#16a085;">Background and Objective:</span></strong></span>&nbsp;Hypothyroidism leads to an increased risk of overweight and obesity. This study examined the effect of weight gain caused by hypothyroidism on maternal health (hypertension, gestational diabetes, and miscarriage) for the first time.<br> <span style="color:#ffffff;"><strong><span style="background-color:#16a085;">Materials and Methods:</span></strong></span> This case-control study consisted of 123 pregnant women with clinical hypothyroidism and 242 non-hypothyroid pregnant women as the control group. National guidelines were used to diagnose hypothyroidism in the first trimester. Body mass index (BMI), thyroid-stimulating hormone level, as well as systolic and diastolic blood pressure (BP) were measured. Moreover, fasting blood sugar was assessed during 24-28 weeks of gestation. Data were analyzed by the Chi-square, Student&rsquo;s t-distribution, and logistic regression using the SPSS19 software.<br> <span style="color:#ffffff;"><strong><span style="background-color:#16a085;">Results:</span></strong></span>&nbsp;We found a significant relationship between BMI and hypothyroidism in pregnant women (<em>P</em><0.001). Systolic and diastolic BP in the case group were higher in women with BMI&ge;25 (<em>P</em>=0.017 and <em>P</em>=0.002). Furthermore, diastolic BP had a significant impact on abortion (<em>P</em>=0.018). The rate of abortion increases by 1.042 with 1 mmHg elevation in diastolic BP in pregnant women if the variables maternal age, hypothyroidism, and overweight are constant.<br> <span style="color:#ffffff;"><strong><span style="background-color:#16a085;">Conclusion:</span></strong></span>&nbsp;According to the results of the present study, weight gain in women with hypothyroidism can affect the risk of high diastolic BP and abortion.</span></span></p> Abortion, Hypertension, Hypothyroidism, Obesity, Overweight 279 285 http://journal.zums.ac.ir/browse.php?a_code=A-10-5603-1&slc_lang=en&sid=1 Sahar Mazloomi saharmazloomi1001@yahoo.com 5200319475328460064103 5200319475328460064103 No Dept. of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Narges Alizadeh nargesalizade4230@gmail.com 5200319475328460064104 5200319475328460064104 No Dept.of Obstetrics and Gynecology, Bijar Imam Hossein Hospital, Kurdistan University of Medical Sciences, Kurdistan, Iran Gholamreza Shafiee g.r_shafiee@yahoo.com 5200319475328460064105 5200319475328460064105 Yes Dept. of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Somayeh Ghorbani s.ghorbani.gh@gmail.com 5200319475328460064106 5200319475328460064106 No Dept. of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran Massoume Afsharirad M.afsharirad59@gmail.com 5200319475328460064107 5200319475328460064107 No Dept.of High Risk Pregnancy, Bijar Imam Hossein Hospital, Kurdistan University of Medical Sciences, Kurdistan, Iran