en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:2;"><span lang="EN-GB">Increment in cancer prevalence and subsequent need for chemotherapy leads to distinct kidney-related diseases such as acute kidney injury (AKI). Cisplatin is a common chemotherapeutic agent that </span>has been<span lang="EN-GB"> used in many cancers; however, it can damage renal cells. </span><i>Capparis spinosa</i> is an important therapeutic plant in Persian medicine that encompasses high amounts of bioactive antioxidant components. The current study aimed to evaluate the nephroprotective effects of <i>Capparis spinosa</i> seed hydroalcoholic extract (<span lang="EN-GB">CSSE</span>) against cisplatin-induced nephrotoxicity <i>in vivo</i> through histopathological evaluation.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:2;"><span lang="EN-GB">Forty Sprague Dawley rats weighing within the range of 230&plusmn;20 gr were randomly divided into eight groups including sham, a single-dose cisplatin intraperitoneally (IP) injected group (7 mg/kg), toxic dose CSSE (200 mg/kg) group, and groups with cisplatin 7mg/kg IP and different doses of CSSE. Histopathological changes in the kidney tissues were quantified by the image-J program and analyzed by statistical methods.</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:2;"><span lang="EN-GB">Cisplatin-induced glomerular and tubular injuries in the kidney tissue. A single-dose cisplatin decreased the glomerular area and Bowman&#39;s capsule area, increased Bowman&#39;s space, and induced tubular loss of brush borders, tubular dilatation, tubular cast formation and tubular necrosis. All of the changes were reversed by CSSE significantly.</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:2;"><span lang="EN-GB">Post-CSSE (50 and 100 mg/kg) treatment could protect against cisplatin-induced nephrotoxicity <i>in vivo.</i>&nbsp;More clinical studies are needed to confirm its protective effects on the prevention of kidney injury in chemotherapy receiving patients.</span></span></span></span></p> Capparis spinosa, Persian Medicine, Pathology, Acute kidney injury, Cisplatin. Cancer 73 79 http://journal.zums.ac.ir/browse.php?a_code=A-10-6308-1&slc_lang=en&sid=1 Fariba Mahmoodpoor mahmoodpoorfa@zums.ac.ir 5200319475328460074788 5200319475328460074788 No Dept. of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Seyed Hojjat Hosseini h.hosseini@zums.ac.ir 5200319475328460074789 5200319475328460074789 No Dept. of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Elham Ahmadian ahmadian.elham@yahoo.com 5200319475328460074790 5200319475328460074790 No Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Mohammadreza Ardalan ardalan34@yahoo.com 5200319475328460074791 5200319475328460074791 No Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Koorosh Kamali drkamali@zums.ac.ir 5200319475328460074792 5200319475328460074792 No Dept. of Public Health, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran Sepideh Zununi Vahed sepide.zununi@gmail.com 5200319475328460074793 5200319475328460074793 No Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Saeed Sardari ssardari@zums.ac.ir 5200319475328460074794 5200319475328460074794 No Dept. of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Narjes Khavasi nxavasi@zums.ac.ir 5200319475328460074795 5200319475328460074795 Yes Dept. of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran