Journal of Advances in Medical and Biomedical Research

en Efficacy of an Herbal Formulation (Taryaqe Vabaei) in Alleviating Symptoms of Upper Respiratory Tract Infections: A Randomized Double-Blind, Placebo-Controlled Clinical Trial Clinical Medicine Clinical Medicine کارآزمایی بالینی Clinical Trials Background and Objectives: This randomized, double-blind, placebo-controlled clinical trial investigates the efficacy of Taryaqe Vabaei, a traditional herbal formulation consisting of Aloe barbadensis, Commiphora myrrh, and Crocus sativus, in alleviating Upper respiratory tract infections (URTIs) symptoms. Materials and methods: Sixty-six participants aged 25–60 with mild URTI symptoms were randomized into two groups. The intervention group received 500 mg of Taryaqe Vabaei twice daily for 14 days, while the control group received a placebo. Symptom severity was the primary outcome. For normally distributed data, independent and paired t-tests were used; for non-normally distributed data, the Mann-Whitney U and Wilcoxon signed-rank tests were applied. Categorical variables were analyzed using the chi-square test (SPSS v.26, significance at P<0.05). Results: The intervention group showed significantly faster recovery times for body pain (0.85±1.23 vs. 4.36±1.82 days, p<0.001), sore throat (p<0.001), runny nose (p<0.001), cough (p<0.001), sneezing (p<0.001), fever (p<0.001), and confusion (0.71±1.43 vs. 0.06±0.36 days, p=0.01). Symptom severity decreased by 40% after one week in the intervention group, with significant improvements in overall symptom scores compared to placebo. Conclusion: Although Taryaqe Vabaei showed promising results in reducing URTI symptoms, larger, longer-term studies are required to confirm its efficacy, explore safety profiles, and assess potential interactions with conventional treatments. These findings highlight the potential of Taryaqe Vabaei as an effective complementary therapy for managing URTIs.   Aloe barbadensis, Commiphora myrrh, Crocus sativus, Persian Medicine, Complementary Medicine, Respiratory Tract Infections.medicine 26 26 http://journal.zums.ac.ir/browse.php?a_code=A-10-7287-1&slc_lang=en&sid=1 Mehdi Zarvandi Dr.Zarvandi@Gums.ac.ir 5200319475328460089031 5200319475328460089031 No Department of Traditional Persian Medicine, Golestan University of Medical Sciences, Gorgan, Iran Abdolhalim Rajabi rajabiepid@gmail.com 5200319475328460089032 5200319475328460089032 No Asistant Professor of Epidemiology, Department of Bistatistitics and Epidemiology, School of Health, Golestan University of Medical Siences Fariba Esmaeil Mosharrafi Email:F.e.mosharrafi@gmail.com 5200319475328460089033 5200319475328460089033 No Student in Persian Medicine,Department of Traditional Persian Medicine, Golestan University of Medical Sciences, Gorgan, Iran.( Saeed Seprhrikia Dr.sepehrikia@yahoo.com 5200319475328460089034 5200319475328460089034 Yes d- Neyshabur University of Medical Sciences, Neyshabur, Iran