en Life Science Life Science مقاله پژوهشی Original Research Article <span style="font-size:12pt"><span style="line-height:115%"><span style="font-family:Aptos,sans-serif"><span style="font-family:&quot;Times New Roman&quot;,serif"><strong>Background</strong>: This histological study aimed to evaluate the effects of the local application of angiopoietin 1 on tooth development in the upper molar area in neonatal rats at 16 days.<br> <strong>Materials And Methods</strong>: This study enrolled 12 neonatal rats weighing 3.5&ndash;4 g maintained in a controlled environment with respect to temperature and access to food and water. The animals in the experimental group (n=6) were administered 10 &micro;L of angiopoietin 1 in the upper right molar area, while saline was administered to those in the control group (n=6). The animals were sacrificed on day 16.<br> <strong>Results</strong>: Local application of angiopoietin 1 protein significantly accelerated the process of tooth development in each of the 6 samples in the experimental group. Early tooth tissue deposition was observed in the experimental group, as evidenced by the increase in the thickness of dentin and enamel, along with an increase in the number of odontoblasts, fibroblasts, and blood vessels, compared with the control group. Statistically, highly significant differences were observed in all variables between the two groups (p<0.05).<br> <strong>Conclusions</strong>: Local application of angiopoietin 1 accelerated tooth development compared with the control group.</span></span></span></span><br> &nbsp; tooth development, angiopoietin 1, angiogenesis, VEGF, Enamel organ 24 24 http://journal.zums.ac.ir/browse.php?a_code=A-10-7469-1&slc_lang=en&sid=1 Al-Hussein Ali Mohammed Hussein alhusain@alameed.edu.iq 5200319475328460089016 5200319475328460089016 Yes College Of Dentistry, University Of Al-Ameed, kerbala, Iraq Enas Fadhil Kadhim dr.enas.fadhil4@codental.uobaghdad.edu.iq 5200319475328460089017 5200319475328460089017 No College Of Dentistry, University Of Baghdad, Baghdad, Iraq