Neuroleptic Malignant Syndrome (NMS) is a rare but potentially fatal problem induced by the consumption of antipsychotic drugs, especially traditional drugs which are more common in youngsters and males. This paper describes the first reported case of a clinical presentation of NMS (induced by the consumption of Risperidone) in an old woman, who was suffering from psychotic processes. Due to psychotic depression and with differential diagnosis of schizoaffective, the woman had been prescribed a low and medium dosage of Risperidone, but she suddenly and unexpectedly developed clinical NMS. Despite special treatments and services, she passed away after 14 days. In spite of rare universal reports regarding the development of NMS induced by the consumption of Risperidone, so far no occurrence of NMS in aged women has been reported.