دوره 33، شماره 157 - ( 2-1404 )
جلد 33 شماره 157 صفحات 95-85 |
برگشت به فهرست نسخه ها
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Eslami Aliabadi H, Saedikia A, Hosseinzadeh M. The Effect of Peppermint on Chemotherapy Induced Nausea and Vomiting (CINV): A Systematic Review and Meta-Analysis. J Adv Med Biomed Res 2025; 33 (157) :85-95
URL: http://journal.zums.ac.ir/article-1-7600-fa.html
URL: http://journal.zums.ac.ir/article-1-7600-fa.html
The Effect of Peppermint on Chemotherapy Induced Nausea and Vomiting (CINV): A Systematic Review and Meta-Analysis. Journal of Advances in Medical and Biomedical Research. 1404; 33 (157) :85-95
چکیده: (532 مشاهده)
Background & Objective: Nausea and vomiting induced by chemotherapy represent significant challenges for cancer patients, adversely affecting their quality of life. Aromatherapy, particularly the use of peppermint essential oil, has gained attention as a complementary approach. This study aims to investigate the effects of peppermint essential oil on alleviating these symptoms.
Materials & Methods: This meta-analysis was conducted in accordance with the PRISMA-P 2015 guidelines and involved a comprehensive search of reputable databases, including MEDLINE/PubMed and Cochrane, up to August 1, 2023.Only randomized controlled trials (RCTs) that examined the effects of peppermint essential oil on nausea and vomiting in cancer patients were included in the study. The quality of the studies was assessed, and data extraction. Statistical analysis was performed using Stata V.17 software.
Results: The conducted meta-analysis demonstrated that the use of peppermint compounds significantly reduces the severity of nausea and vomiting in cancer patients undergoing chemotherapy, because the confidence interval does not include zero, indicating a positive effect (SMD: 0.643, 95% CI: 0.458-0.829). Based on Egger's test and Funnel Plot, no significant publication bias was detected (P=0.125). However, a relatively high level of heterogeneity was observed in the combined studies (P=0.020, I²=60.1%), necessitating the use of a random effects model (REM) for data analysis. This heterogeneity could be due to differences in the type of interventions and assessment tools instruments. These results underscore the efficacy of peppermint essential oil in mitigating chemotherapy-induced nausea and vomiting symptoms.
Conclusion: Aromatherapy with peppermint essential oil may serve as an effective and cost-efficient treatment for alleviating nausea and vomiting symptoms resulting from chemotherapy. Offering a promising foundation for future research and clinical application.
نوع مطالعه: متا آنالیز |
موضوع مقاله:
Health Improvement Strategies
دریافت: 1403/10/21 | پذیرش: 1404/2/8 | انتشار: 1404/3/8
دریافت: 1403/10/21 | پذیرش: 1404/2/8 | انتشار: 1404/3/8
فهرست منابع
1. Dadkhah B, Anisi E, Mozaffari N, Amani F, Pourghasemian M. Effect of music therapy with periorbital massage on chemotherapy-induced nausea and vomiting in gastrointestinal cancer: a randomized controlled trail. J Caring Sci. 2019;8(3):165-71. [DOI:10.15171/jcs.2019.024] [PMID] [PMCID]
2. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. [DOI:10.3322/caac.21660] [PMID]
3. Dolatkhah R, Somi MH, Kermani IA, Ghojazadeh M, Jafarabadi MA, Farassati F, et al. Increased colorectal cancer incidence in Iran: a systematic review and meta-analysis. BMC Public Health. 2015;15:1-14. [DOI:10.1186/s12889-015-2342-9] [PMID] [PMCID]
4. Bosak S, Dashtbozorgi B, Hoseini M, Laifi M, Rezaei A. The effect of massage therapy on nausea in patients who undergo chemotherapy for breast cancer. Jundishapur J Chronic Dis Care. 2012;1(1).
5. Yan Y, López‐Alcalde J, Zhang L, Siebenhüner AR, Witt CM, Barth J. Acupuncture for the prevention of chemotherapy‐induced nausea and vomiting in cancer patients: A systematic review and meta‐analysis. Cancer Med. 2023;12(11):12504-17. [DOI:10.1002/cam4.5962] [PMID] [PMCID]
6. Moradi Y, Jafarizadeh H, Asghari R, Mirzamohammadi O, Alinejad V. Single and combined use of Benson relaxation technique and oxygen therapy on chemotherapy-induced nausea and vomiting in gastric cancer patients. EXPLORE. 2023;19(4):587-93. [DOI:10.1016/j.explore.2022.11.006] [PMID]
7. Hata A, Okamoto I, Inui N, Okada M, Morise M, Akiyoshi K, et al. Randomized, double-blind, phase III study of fosnetupitant versus fosaprepitant for prevention of highly emetogenic chemotherapy-induced nausea and vomiting: CONSOLE. J Clin Oncol. 2022;40(2):180-8. [DOI:10.1200/JCO.21.01315] [PMID] [PMCID]
8. Navari RM. Olanzapine for the prevention of chemotherapy-induced nausea and vomiting. Management of Chemotherapy-Induced Nausea and Vomiting: New Agents and New Uses of Current Agents. 2016:107-20. [DOI:10.1007/978-3-319-27016-6_6]
9. Wu Z, Fu X, Jing H, Huang W, Li X, Xiao C, et al. Herbal medicine for the prevention of chemotherapy-induced nausea and vomiting in patients with advanced colorectal cancer: A prospective randomized controlled trial. J Ethnopharmacol. 2024;325:117853. [DOI:10.1016/j.jep.2024.117853] [PMID]
10. Roila F, Molassiotis A, Herrstedt J, Aapro M, Gralla RJ, Bruera E, et al. 2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting in advanced cancer patients. Ann Oncol. 2016;27(suppl 5):v119-v33. [DOI:10.1093/annonc/mdw270] [PMID]
11. Wagland R, Richardson A, Armes J, Hankins M, Lennan E, Griffiths P. Treatment-related problems experienced by cancer patients undergoing chemotherapy: a scoping review. Eur J Cancer Care (Engl). 2015;24(5):605-17. [DOI:10.1111/ecc.12246] [PMID]
12. Supportive PDQ, Board PCE. Nausea and vomiting related to cancer treatment (PDQ®). In PDQ Cancer Information Summaries. 2023. Bethesda, Maryland, U.S.: National Cancer Institute.
13. Farrell C, Brearley SG, Pilling M, Molassiotis A. The impact of chemotherapy-related nausea on patients' nutritional status, psychological distress and quality of life. Support Care Cancer. 2013;21(1):59-66. [DOI:10.1007/s00520-012-1493-9] [PMID]
14. Krikorian S, Pories S, Tataronis G, Caughey T, Chervinsky K, Lotz M, et al. Adherence to oral chemotherapy: Challenges and opportunities. J Oncol Pharm Pract. 2019;25(7):1590-8. [DOI:10.1177/1078155218800384] [PMID]
15. Tipton JM, McDaniel RW, Barbour L, Johnston MP, Kayne M, LeRoy P, et al. Putting evidence into practice: evidence-based interventions to prevent, manage, and treat chemotherapy-induced nausea and vomiting. Clin J Oncol Nurs. 2007;11(1):69-78. [DOI:10.1188/07.CJON.69-78] [PMID]
16. Doorenbos AZ. Oncology Nursing Society Putting Evidence Into Practice® resources: Where are we now and what is next? Number 6/December 2008. 2008;12(6):965-70. [DOI:10.1188/08.CJON.965-970] [PMID]
17. Price S, Price L. Aromatherapy for health professionals. No. Ed.2, pp. 391. 1999. Edinburgh, UK: Churchill Livingstone.
18. Ertürk NE, Taşcı S. The effects of peppermint oil on nausea, vomiting and retching in cancer patients undergoing chemotherapy: An open label quasi-randomized controlled pilot study. Complement Ther Med. 2021;56:102587. [DOI:10.1016/j.ctim.2020.102587] [PMID]
19. Ali B, Al-Wabel NA, Shams S, Ahamad A, Khan SA, Anwar F. Essential oils used in aromatherapy: A systemic review. Asian Pac J Trop Bio. 2015;5(8):601-11. [DOI:10.1016/j.apjtb.2015.05.007]
20. Zorba P, Ozdemir L. The Preliminary Effects of Massage and Inhalation Aromatherapy on Chemotherapy-Induced Acute Nausea and Vomiting: A Quasi-Randomized Controlled Pilot Trial. Cancer Nurs. 2018;41(5):359-66. [DOI:10.1097/NCC.0000000000000496] [PMID]
21. Eghbali M, Varaei S, Yekaninejad MS, Mohammadzadeh F, Shahi F. To what extend aromatherapy with peppermint oil effects on chemotherapy induced nausea and vomiting in patient diagnosed with breast cancer? A randomized controlled trial. J Hematol Thromboembolic Dis. 2017;5(06).
22. Mapp CP, Hostetler D, Sable JF, Parker C, Gouge E, Masterson M, et al. Peppermint Oil: Evaluating Efficacy on Nausea in Patients Receiving Chemotherapy in the Ambulatory Setting. Clin J Oncol Nurs. 2020;24(2):160-4. [DOI:10.1188/20.CJON.160-164] [PMID]
23. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1. [DOI:10.1186/2046-4053-4-1]
24. Sterne JA, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. bmj. 2019;366. [DOI:10.1136/bmj.l4898] [PMID]
25. Haddadi M, Ganjloo J, Hashemifard HR, Tabarraie Y. The effect of sucking bits of ice containing mint (mentha) extract on nausea and vomiting resulted of chemotherapy in patients suffering from malignant cancer. Iran J Breast Dis. 2017;9(4):7-14. [DOI:10.5812/jmb.9832]
26. Demont LM, Patterson A, Reich RR, Mason TM. Reduction of Chemotherapy-Induced Nausea and Vomiting: A Pilot Study of Essential Oils in the Autologous Blood and Marrow Transplantation Population. Clin J Oncol Nurs. 2023;27(2):155-63.
27. Jafarimanesh H, Akbari M, Hoseinian R, Zarei M, Harorani M. The Effect of Peppermint (Mentha piperita) Extract on the Severity of Nausea, Vomiting and Anorexia in Patients with Breast Cancer Undergoing Chemotherapy: A Randomized Controlled Trial. Integr Cancer Ther. 2020;19: 1534735420967084. [DOI:10.1177/1534735420967084] [PMID] [PMCID]
28. Tayarani-Najaran Z, Talasaz-Firoozi E, Nasiri R, Jalali N, Hassanzadeh M. Antiemetic activity of volatile oil from Mentha spicata and Mentha × piperita in chemotherapy-induced nausea and vomiting. Ecancermedicalscience. 2013;7:290.
29. Rajabalizadeh R, Ghasemzadeh Rahbardar M, Hosseinzadeh H. Medicinal herbs in treating chemotherapy-induced nausea and vomiting: A review. Phytother Res. 2022;36(10):3691-708. [DOI:10.1002/ptr.7563] [PMID]
30. Heimes K, Hauk F, Verspohl EJ. Mode of action of peppermint oil and (-)-menthol with respect to 5-HT3 receptor subtypes: binding studies, cation uptake by receptor channels and contraction of isolated rat ileum. Phytother Res. 2011;25(5):702-8. [DOI:10.1002/ptr.3316] [PMID]
31. Lummis SC. 5-HT(3) receptors. J Biol Chem. 2012; 287(48):40239-45. [DOI:10.1074/jbc.R112.406496] [PMID] [PMCID]
32. Abdolhosseini S, Mokaberinejad R, Aliasl J, Aliasl F. Medicinal plants proposed for nausea and vomiting of pregnancy: a review study based on Iranian traditional medicine. Iran J Obstet Gynecol Infertil. 2017; 20(supplement):1-8.
33. Kurt B, Kapucu S, Çakmak Öksüzoğlu B. Effects of Oral Cryotherapy on Anticipatory, and Acute Nausea and Vomiting in Patients with Breast Cancer Undergoing Adjuvant Chemotherapy: A Randomized Controlled Clinical Trial. Clin Breast Cancer. 2024; 24(2):112-21. [DOI:10.1016/j.clbc.2023.10.012] [PMID]
34. Eghbali M, Varaei S, Hosseini M, Yekaninejad MS, Shahi F. The Effect of Aromatherapy with Peppermint Essential Oil on Nausea and Vomiting in the Acute Phase of Chemotherapy inPatients with Breast Cancer. J Babol Univ Med Sci. 2018;20(9):66.
35. Yudha MB, Makiyah SNN. Effectiveness of Aromatherapy Against Nausea and Vomiting in Patients Cancer Undergoing Chemotherapy: Literature Review. J Aisyah: Jurnal Ilmu Kesehatan. 2021;6(4):693-700. [DOI:10.30604/jika.v6i4.700]
36. Howard S, Hughes BM. Expectancies, not aroma, explain impact of lavender aromatherapy on psychophysiological indices of relaxation in young healthy women. Br J Health Psychol. 2008;13(Pt 4):603-17. [DOI:10.1348/135910707X238734] [PMID]
37. Lane B, Cannella K, Bowen C, Copelan D, Nteff G, Barnes K, et al. Examination of the effectiveness of peppermint aromatherapy on nausea in women post C-section. J Holist Nurs. 2012;30(2):90-104. [DOI:10.1177/0898010111423419] [PMID]
38. Tisserand R, Young R. Essential oil safety: a guide for health care professionals: Elsevier Health Sciences. 2nd Ed. 2013. London, U.K.: Churchill Livingstone, Inc.
39. Sahandi MS, Mehrafarin A, Khalighi-Sigaroodi F, Sharifi M, Badi HN. Review on anatomical, phytochemical and pharmacological properties of peppermint (Mentha piperita L.). J Med Plants. 2019; 18(69):16-33.
40. Arafa Badr E, Mohamed Hassan H, Abd-Elsalam Gaafer Y, Youssef Kamal M. Effect of Peppermint Inhalation on Chemotherapy Induced-Nausea and Vomiting in Children with Leukemia. Alex Sci Nurs J. 2024;26(1):157-69. [DOI:10.21608/asalexu.2024.354353]
41. Maghami M, Afazel MR, Azizi-Fini I, Maghami M. The effect of aromatherapy with peppermint essential oil on nausea and vomiting after cardiac surgery: A randomized clinical trial. Complement Ther Clin Pract. 2020;40:101199. [DOI:10.1016/j.ctcp.2020.101199] [PMID]
42. Agustini IGAR, Wulandari MRS, Dewi KPP. The Effect of Peppermint Aromatherapy on The Incidence of Emesis Gravidarum in The First and Second Trimester Pregnant Women in The Working Area of South Denpasar Public Health Center I, Denpasar City. J Aisyah: Jurnal Ilmu Kesehatan. 2022;7(2):467-72. [DOI:10.30604/jika.v7i2.1003]
43. Amzajerdi A, Keshavarz M, Montazeri A, Bekhradi R. Effect of mint aroma on nausea, vomiting and anxiety in pregnant women. J Fam Med PrimCare. 2019;8(8): 2597-601. [DOI:10.4103/jfmpc.jfmpc_480_19] [PMID] [PMCID]
44. Palatty PL, Dhanya S, Varija RS, Rajesh A, Suresh R, Baliga MS. Dietary agents in the prevention of radiation-induced nausea and vomiting (RINV): review addressing the scientific observations, benefits, lacunae and future direction. Int J Radiat Biol. 2024;100(8):1143-54. [DOI:10.1080/09553002.2024.2309899] [PMID]
45. Amzajerdi A, Keshavarz M, Sarvi F, Bekhradi R. The time effect of Mint and Lavender oil on nausea and vomiting of pregnancy based on Rhodes index. Iran J Obstet Gynecol Infertil. 2022;25(5):67-77.
46. Joulaeerad N, Ozgoli G, Hajimehdipoor H, Ghasemi E, Salehimoghaddam F. Effect of Aromatherapy with Peppermint Oil on the Severity of Nausea and Vomiting in Pregnancy: A Single-blind, Randomized, Placebo-controlled trial. J Reprod Infertil. 2018;19(1): 32-8.
47. Pasha H, Behmanesh F, Mohsenzadeh F, Hajahmadi M, Moghadamnia AA. Study of the effect of mint oil on nausea and vomiting during pregnancy. Iran Red Crescent Med J. 2012;14(11):727-30. [DOI:10.5812/ircmj.3477] [PMID] [PMCID]
| بازنشر اطلاعات | |
 |
این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |