fa بررسی اثر ضددرد تزریق درون بطن مغزی و محیطی JWH133 در موش سوری مقاله پژوهشی Original Research Article <p style="text-align: justify;"><strong>Background & Objective:</strong> &lrm;Cannabinoids have a dose-related antinociceptive effect in animals and humans through Cannabinoid receptors (CB1,CB2). Several &lrm;studies have suggested that CB2 receptors are not expressed in the CNS but others suggest that there are a few, although significant, receptors in that area. To date no studies have been done on the antinociceptive effect of central administration of a CB2 agonist. In this study the central and peripheral analgesic effect of JWH133 (a CB2 agonist) was examined.&lrm;<br> <strong>Materials & Methods:</strong> Male mice were used in this study. The antinociceptive effects of intracerebroventricular (i.c.v.) administration of JWH133 &lrm;using formalin test was studied in stereotaxed mice after one week of &lrm;surgery and the insertion of a stainless steel cannula in the left cerebroventricle. To study peripheral effects of JWH133, the drug was administered intraperitoneally (i.p.).<br> <strong>Results:</strong> The i.c.v injection of JWH133 had no effect but i.p. injection of the drug had analgesic effects.<br> <strong>Conclusion:</strong> The present results may suggest that there are no any effective analgesic CB2 receptors in the CNS.</p> Analgesia (Antinociception), JWH133, CB2, Formalin test. 9 14 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-24&slc_lang=fa&sid=1 Mohammad Reza Jafari محمد رضا جعفری 5200319475328460057810 5200319475328460057810 Yes Somayeh Golmohammadi سمیه گل محمدی 5200319475328460057811 5200319475328460057811 No Fereshteh Ghasvand فرشته غیاثوند 5200319475328460057812 5200319475328460057812 No