fa مقایسه‌ی میزان تقارب الگوی‌های ژنتیکی سویه مایکوباکتریوم توبرکلوزیس با استفاده از تکنیک MIRU-VNTR جدا شده از بیماران مسلول در سال‌های 85 تا 86 مقاله پژوهشی Original Research Article <p style="text-align: justify;"><strong><em>Background and Objective:</em></strong> In recent decades, epidemiology has significantly been considered in hygienic studies and disease control, and has made a way into all the programs and hygiene policies. By examining the convergence of harmful lineage genetic patterns, the common infectious resources among the patients can be inferred. The purpose of this study was to compare the <em>Mycobacterium Tuberculosis</em> genetic patterns convergence isolated from patients infected with <em>Mycobacterium Tuberculosis</em> by MIRU-VNTR technique.<br> <strong><em>Materials and Methods:</em></strong> After isolation the samples from Lowenstein Jensen culture environment and taking segregate tests and drug susceptibility, the DNA was extracted using CTAB/Nacl technique. The genetic patterns of lineages were calculated according to 12 loci format with MIRU-VNTR technique. Demographic and molecular information of patients was used for epidemiological purposes.<br> <strong><em>Results:</em></strong> After performing drug sensitivity test, 65/140 (64/4%) samples fall into MDR, 29 (20/7%) samples in non MDR category, and the rest of them were among drug &ndash; sensitive lineages. Lineage genetic pattern analysis indicated that 49 (35%) of samples related to Delhi/CAS, 28 (20%) to Uganda I, 16 (11/4%) to New I, 1 (0.7%) to EAI, 3(2/1%) to Haarlem, and 5(3/5%) to H37RV families.<br> <strong><em>Conclusion: </em></strong>The genetic pattern convergence comparison exhibited that the most common and variant genetic patterns was seen in Tehran province which were mostly connected to south (from the South of Tehran to Azadi Square) and to the border cities neighboring Afghanistan, Iraq, Turkmenistan and cities with extreme percentage of immigration, all of which signified shared polluted resources among patients.</p> Mycobacterium tuberculosis, MIRU-VNTR, Epidemiology 25 36 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-577&slc_lang=fa&sid=1 Mehdi Jafarian مهدی جعفریان mehdijafariandormency@gmail.com 5200319475328460060144 5200319475328460060144 Yes Islamic Azad University, Jahrom Branch, The Research Center of Mycobacteriology, Jahrom, Iran کارشناس ارشد میکروب‌شناسی، دانشگاه آزاد اسلامی واحد جهرم، مرکز تحقیقات مایکوباکتریولوژی، باشگاه پژوهشگران جوان Parisa Farnia پریسا فرنیا 5200319475328460060145 5200319475328460060145 No Mycobacteriology Research Center , Shahid Beheshti University of Medical Sciences, Tehran, Iran دکترای میکروبیولوژی پزشکی، دانشیار دانشگاه علوم پزشکی و خدمات پزشکی بهداشتی درمانی شهید بهشتی، مرکز تحقیقات مایکوباکتریولوژی Mohadeseh Mozafari محدثه مظفری 5200319475328460060146 5200319475328460060146 No Qom Azad University of Medical Sciences, Qom, Iran دانشجوی کارشناسی ارشد میکروب‌شناسی، دانشگاه آزاد اسلامی واحد قم، مرکز تحقیقات مایکوباکتریولوژی Mojtaba Ahmadi مجتبی احمدی 5200319475328460060147 5200319475328460060147 No Mycobacteriology Research Center , Shahid Beheshti University of Medical Sciences, Tehran, Iran کارشناس میکروب‌شناسی، آزمایشگاه رفرانس سل کشوری، مرکز تحقیقات مایکوباکتریولوژی Mohammad Reza Masjiedi محمد‌رضا مسجدی 5200319475328460060148 5200319475328460060148 No The Research Center of TB and Lung Diseases, Shahid Beheshti University of Medical Sciences. Tehran, Iran فوق تخصص ریه، استاد دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید بهشتی، مرکز تحقیقات سل و بیماری‌های ریوی Ali Akbar Velayati علی‌اکبر ولایتی 5200319475328460060149 5200319475328460060149 No The Research Center of TB and Lung Diseases, Shahid Beheshti University of Medical Sciences. Tehran, Iran فوق تخصص عفونی اطفال، استاد دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید بهشتی، مرکز تحقیقات سل و بیماری‌های ریوی