fa بررسی تأثیر سولفات روی خوراکی بر روند درمان کودکان مبتلا به گاستروآنتریت حاد مقاله پژوهشی Original Research Article <p style="text-align: justify;"><strong><em>Background and Objective: </em></strong>Gastroenteritis is a major cause of mortality and morbidity among infants and children around the world. Zinc with increasing the absorbent capacity of enteric villous cells and decreasing the enteric gram negative bacteria and blocking chloride excretion leads to cell healing and helps diarrhea to resolve faster. The present study evaluates the effect of oral zinc sulfate syrup on infants of the city of<br> Zanjan- Iran.<span dir="RTL"></span><br> <strong><em>Materials and Methods:</em></strong> In this randomized double blind trial, 400 hospitalized infants (age range of 6 to 24 months) with acute gastroenteritis were divided into two equal groups. The case group received 20 mg of daily oral zinc sulfate; whereas control group took the placebo. Data was gathered with questionnaires and recorded precisely over 10 days and then analyzed with independent statistical t<a name="OLE_LINK58"></a><a name="OLE_LINK57">-test and </a>Mann-Whitney<br> U-test.<br> <strong><em>Results:</em></strong> Findings indicated that the frequency&nbsp; of diarrhea in the case group was less than the control group and weight gain after 10 days in the case <a name="OLE_LINK14"></a><a name="OLE_LINK13">group</a> was more than the control group(P<0.0001). Meanwhile, there was no significant difference in hospitalization period and duration of diarrhea.<span dir="RTL"></span><br> <strong><em>Conclusion:</em></strong> The results of this study pointed out that there is a meaningful relation between times of<br> diarrhea and weight gain in infants with acute gastroenteritis receiving oral zinc sulfate. Thus, prescription of zinc sulfate for infants with acute diarrhea for a period of 10 to 14 days is suggested.</p> Keywords: Gastroenteritis, Zinc sulfate, Infants 58 65 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-592&slc_lang=fa&sid=1 Seyed Zohreh Torabi سید زهره ترابی drztorabi@yahoo.com 5200319475328460060110 5200319475328460060110 Yes Aayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Reza Abbaszadeh رضا عباس‌زاده 5200319475328460060111 5200319475328460060111 No Aayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Akefeh Ahmadiafshar عاکفه احمدی‌افشار 5200319475328460060112 5200319475328460060112 No Aayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran