fa بررسی سطح هموسیستئین پلاسما در بیماران دیابتی نوع 2 تحت درمان با متفورمین و ارتباط آن با ظرفیت تام آنتی‌اکسیدانی، مالون دی آلدهید، کراتی‌نین سرم، مقاومت انسولینی و کنترل گلایسمیک مقاله پژوهشی Original Research Article <p style="text-align: justify;"><strong><em>Background and Objective</em></strong>: In patients with diabetes, elevated homocysteine levels have been reported to be associated with endothelial dysfunction, insulin resistance, dyslipidemia, poor control of disease, nephropathy, macroangiopathy and oxidative stress. Thus, this observational study was performed to determine the plasma homocysteine level and its correlation with clinical, biochemical and nutritional variables.<br> <strong><em>Materials and Methods</em></strong><strong>:</strong> This study was performed on 70 men with type 2 diabetes under metformin<br> (at least 1500 mg daily) treatment. Regarding plasma homocysteine, patients were divided into two groups: 31patients with normal homocysteine (group 1: Hcy<15 &micro;mol/L) and 39 patients with hyperhomocysteinemia (group 2: Hcy>15 &micro;mol/L).<br> <strong><em>Results:</em></strong> 55.1% patients had hyperhomocysteinemia but none of them had folate and B12 deficiency. Significant differences between the two groups, were found for serum folate, total antioxidant capacity and creatinine. No differences were found for insulin resistance and glycemic control. Multiple stepwise linear regression analysis using plasma homocysteine as a dependent variable and all other clinical and laboratory parameters as independent variables indicated that age (<span dir="RTL">&beta;</span>=0.344), creatinine (<span dir="RTL">&beta;</span>=0.351), vitamin B12 (<span dir="RTL">&beta;</span>=0.235), total antioxidant capacity (<span dir="RTL">&beta;</span>=0.285) and malondialdehyde (<span dir="RTL">&beta;</span>=0.245) were independently associated with homocysteine concentration. No correlation was found between the homocysteine and glycemic control, HOMA-IR and intake of B vitamins and caffeine.&nbsp;<br> <strong><em>Conclusion</em></strong><strong>:</strong> Further studies with a large sample size are required to assess the association of plasma homocysteine with total antioxidant capacity and other biomarkers of oxidative stress in type2 diabetes.</p> Homocysteine, Glycemic control, Insulin resistance, Type II Diabetes Mellitus, Total Antioxidant capacity 1 10 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-599&slc_lang=fa&sid=1 Vahedeh Aghamohammadi وحیده آقامحمدی خیاوی 5200319475328460060091 5200319475328460060091 No Nutritional Research Center, Dept. of Biochemistry & Nutrition, Faculty of Health &Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. کارشناس ارشد علوم تغذیه، دانشگاه علوم پزشکی تبریز Bahram Pourghassem Gargari بهرام پور قاسم گرگری pourghassemb@tbzmed.ac.ir 5200319475328460060092 5200319475328460060092 Yes Nutritional Research Center, Dept. of Biochemistry & Nutrition, Faculty of Health &Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. دکترای علوم تغذیه، دانشیار دانشگاه علوم پزشکی تبریز، مرکزتحقیقات تغذیه Aliakbar Aliasgharzadeh اکبرعلی عسگرزاده 5200319475328460060093 5200319475328460060093 No Faculty of Medicine, Endocrine and Metabolism Section, Imam Reza Teaching Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. فوق تخصص غدد درون ریز ومتابولیسم،دانشیار دانشگاه علوم پزشکی تبریز