fa تاثیر مصرف حاد قره قات (Vaccinium Myrtilus L) بر ریسک فاکتورهای بیوشیمیایی آترواسکلروز در خرگوش‌های نر نیوزلندی کارآزمایی بالینی Clinical Trials <p>Background and Objective: The increase in the blood concentration of lipids after meals has a significant effect on induction of atherosclerosis. Vaccinium myrtilus has an antioxidant activity, and in this study, we aimed to determine the effects of this plant on atherosclerosis risk factors. Material and Methods: In an experimental study, 24 male New Zealand rabbits were randomly designated into three groups of 8 rabbits: Group 1, normal diet Group 2, a diet containing 1 % cholesterol and Group 3, a diet containing 1% cholesterol and 2% Vaccinium myrtilus powder. The blood glucose, total cholesterol (TC), triglyceride (TG), apolipoprotein B (ApoB), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), LDL-C (low density lipoprotein), nitrite, nitrate, fibrinogen, and factor VII, which are considered as atherosclerosis risk factors, were measured before the experiment and 3 hours after feeding. The data were analyzed using One-Way Analysis of ANOVA. The P-values below 0.05 (P<0.05) were considered as significant. Results: Consumption of Vaccinium myrtilus significantly decreased the concentrations of LDL-C, TC, aminotransaminases (AST, ALT), ApoB, and fibrinogen compared to the hyper-cholesterolemic diet group (P<0.05). However, there were no significant differences was found between the group taking Vaccinium myrtilus and hyper-cholesterolemic diet group with regard to the serum glucose, TG, factor VII, nitrite, and nitrate (P>0.05). Conclusion: The results of this study show that acute consumption of Vaccinium myrtilus might have a protective effect on some atherosclerosis risk factors.</p> Keywords: Vaccinium myrtilus, Atherosclerosis, Hyperlipidemia, Cholesterol, Triglyceride, Atherosclerosis risk factors 14 23 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-625&slc_lang=fa&sid=1 Mahbobeh Setorki محبوبه سترکی 5200319475328460059928 5200319475328460059928 No Dept of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran Mahmoud Rafieian محمود رفیعیان rafieian@yahoo.com 5200319475328460059929 5200319475328460059929 Yes Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Esfandiar Heidarian اسفندیار حیدریان 5200319475328460059930 5200319475328460059930 No Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Keyhan Ghatreh کیهان قطره 5200319475328460059931 5200319475328460059931 No Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Najmeh Shahinfard نجمه شاهین فرد 5200319475328460059932 5200319475328460059932 No Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Roya Ansari رویا انصاری 5200319475328460059933 5200319475328460059933 No Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Zahra Frozandeh زهرا فروزنده 5200319475328460059934 5200319475328460059934 No Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran