fa بررسی اثر سینرژیسمی آنتی‌بیوتیک‌های پلی‌میکسین B سولفات و تری متوپریم بر یرسینیاانتروکلی‌تیکا و دیگر گونه‌های وابسته کارآزمایی بالینی Clinical Trials <p>Background and Objectives: Previous studies have shown that polymyxin B sulfate and trimthoprim antibiotics are not individually effective on Yersinia enterocolitica and their closely related species. The aim of this study was to evaluate the synergistic effect of above antibiotics on Y. enterocolitica and their closely related species, from the clinical and the natural environment specimen collected in Iran, and compare them with the isolates that that were obtained from the Pasteur institute collection in France. Materials and Methods: In total, 73 species from Iran and 25 from the Pasteur institute in France were tested. The microdilution method was used for the MIC according to the standard protocol. Results: The synergistic effect was seen in all tested samples. However, the human species from the Pasteur institute were more sensitive than the Iranian human and the environmental species were less sensitive than clinical. The Y. enterocolitica isolates were less sensitive than the related species such as Y. intermedia, Y. fredriksenii, and Y. kristensenii. Conclusion: The synergistic effect polymyxin B sulfate and trimthoprim were more evident on other closely related Yersinia species Y. enterocolitica.</p> Keywords: Yersinia enterocolitica, Synergysm, Polymyxin B sulphate, Trimethoprim 34 43 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-627&slc_lang=fa&sid=1 MohammadMehdi Soltan Dallal محمدمهدی سلطان دلال 5200319475328460059939 5200319475328460059939 No 1,2 Division of Microbiology, Dept. of Pathobiology, School of Public Health, Tehran University of Medical Sciences (TUMS). Tehran, Antimicrobial Resistant Research Center, Tehran University of Medical Sciences, Tehran, IranIran Siamak Hidarzadeh سیامک حیدرزاده 5200319475328460059940 5200319475328460059940 No Division of Microbiology, Dept. of Pathobiology, School of Public Health, Tehran University of Medical Sciences (TUMS). Tehran, Iran Mohammad Azarsa محمد آذرسا 5200319475328460059941 5200319475328460059941 No Division of Microbiology, Dept. of Pathobiology, School of Public Health, Tehran University of Medical Sciences (TUMS). Tehran, Iran Ronak Bakhtiari روناک بختیاری 5200319475328460059942 5200319475328460059942 No Division of Microbiology, Dept. of Pathobiology, School of Public Health, Tehran University of Medical Sciences (TUMS). Tehran, Iran MohammadKazem Sharifi Yazdi محمدکاظم شریفی یزدی mksharifi@tums.ac.ir 5200319475328460059943 5200319475328460059943 Yes 3,4Dept. of Laboratory, School of Para Medical Sciences, Tehran University of Medical Sciences. Tehran, Iran,Zonotic Research Center, Tehran University of Medical Sciences, Tehran, Iran.