fa مقایسه‌ی اثر تجویز قبل از عمل ترامادول و دارونما در کاهش درد بعد از عمل لاپاراسکوپی‌های تشخیصی زنان <p style="text-align: justify;"><strong><em>Background </em></strong><strong><em>and</em></strong><strong><em> Objective:</em></strong> Tramadol is an analgesic with combined opioid agonist and monoamine reuptake blocker properties which may be useful as a preoperative analgesic and antinociceptive adjuvant. The aim of this study was the evaluation of preoperative tramadol administration on pain intensity, postoperative analgesic consumption and side effects compared to placebo.<br> <strong><em>Materials </em></strong><strong><em>and</em></strong><strong><em> Methods:</em></strong> In this randomized, double-blind, placebo-controlled clinical trial 70 infertile, ASA class I or II patients were scheduled for diagnostic gynecologic laparoscopy. Fifty mg tramadol was injected into 35 patients before the operation and the other 35 patients received normal saline.<br> <strong><em>Results:</em></strong> The patients who received preoperative tramadol, had a lower pain score within six hours after the operation (1.31&plusmn;0.94 compared to 2.93<span dir="RTL">&plusmn;</span>0.55; p< 0.0001). Ten patients (28.57%) in tramadol group and 33 patients in placebo group had post-operative pain (p< 0.0001). The mean consumption of post-operative tramadol was statistically lower in treatment group (9.46 &plusmn;25.92) than in placebo group (45.95 &plusmn; 37.96); (p<0.0001). Post- operative sedation level 15 minutes (p=0.71) and 30 minutes (p=0.88) after the operation had no significant difference between the two groups. The frequency of post-operative nausea in treatment group (5.71 %) was significantly lower than placebo group (25.71 %) ;( p=0.04).<br> <strong><em>Conclusion:</em></strong> Administration of a single dose of tramadol one hour before operation provides effective pre-emptive analgesia in patients undergoing diagnostic gynecologic laparoscopies without affecting sedation level.</p> Tramadol, Pre-emptive analgesia, Postoperative pain, Side effects. 1 8 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-61&slc_lang=fa&sid=1 Simin Atashkhoyi سیمین آتش خویی Siminatashkhoyi@yahoo.com 5200319475328460057875 5200319475328460057875 Yes Tabriz University of Medical Sciences, Tabriz, Iran Mahin Jafari Javid مهین جعفری جاوید 5200319475328460057876 5200319475328460057876 No Tabriz University of Medical Sciences, Tabriz, Iran