fa بررسی ارتباط لیپدهای خون زنان باردار در هفته‌های 13 تا 23 بر مختل شدن تست رقابت گلوکز کارآزمایی بالینی Clinical Trials <p>Background and Objective: Gestational diabetes mellitus (GDM) complicates 3-5% of all pregnancies. Glucose Challenge Test (GCT) is a universal screening test for GDM between 24-28 of gestation. Plasma glucose is measured 1 hr after ingestion of 50g glucose load. The aim of this study was to determine the relationship of plasma lipids in 13-23 weeks of pregnancy with abnormal GCT (Glucose Challenge Test). Materials and Methods: This prospective longitudinal study was carried out during 2010-2011. The subjects comprised 575 pregnant women aged 18-35 years old who had referred to two health centers (Kosar and Shahid Soleymani) in Shahr rey &ndash;Tehran. The subjects were followed until their 24-28 weeks of gestation. Maternal plasma lipid concentrations were measured at 13-23 weeks of gestation and then all participants were screened at 24-28 weeks of gestation with GCT. A value over 140mg/dl in GCT was considered positive. Results: Logistic Regression analyses confirmed that triglyceride (TG) concentration (OR=1.005, 95% CI= 1.001-1.010) associated with abnormal GCT. No evidence of association was found between GCT risk and plasma concentrations of other lipids (i.e., total cholesterol, high-density lipoprotein and low-density lipoprotein). In ROC curve analysis, the TG cut-off point in abnormal GCT was 142.5 mg/dl (with 61.3% sensitivity, 60.1% specificity, 73% PPV and 74.63% NPV). Conclusion: The findings of this study imply that TG level at 13-23 weeks of pregnancy can be considered as a predictor factor for abnormal GCT.</p> Keywords: Gestational diabetes mellitus, Triglyceride, Glucose challenge test, HDL, LDL 65 75 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-714&slc_lang=fa&sid=1 Mitra Arjmandi Far میترا ارجمندی فر ziaei_sa@modares.ac.ir 5200319475328460059563 5200319475328460059563 Yes Dept of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Saeedeh Ziaei سعیده ضیایی 5200319475328460059564 5200319475328460059564 No Dept of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran