fa ارزش اندازه‌گیری کراتین فسفوکیناز در تشخیص بارداری خارج رحمی کارآزمایی بالینی Clinical Trials <p>Background and Objective: Early detection of ectopic pregnancy is crucial in saving fertility. Some chemical biomarkers that can differentiate normal intra uterine pregnancy from ectopic pregnancy have been detected. This study was performed to determine the sensitivity and specificity of serum creatine phosphokinase(CPK) measurement for diagnosis of ectopic pregnancy. Materials and Methods: This study was performed in Kosar Hospital, Qazvin University of Medical Sciences. Twenty six patients with confirmed ectopic pregnancy comprised the study group and 29 cases with normal intrauterine pregnancy less than 12 weeks constituted the control group. The study group was further subdivided into two groups of ruptured and unruptured tubal pregnancy. A blood sample was obtained from each patient on admission and then CPK was measured. The collected data were analyzed using t-test and k2. Then, CPK levels were compared in three groups. Results: The mean CPK levels in the study group (156+ 93.6 IU/ml) were significantly higher than the control group (58.6+31.5 IU/ml) (P =0.0001). Also the mean CPK levels were higher in ruptured (220.8+100.5 IU/ml) than in unruptured cases (104.3+21.4 IU/ml) (P =0.002). Sensitivity, specificity, positive predictive value, and negative predictive values of CPK in diagnosis of tubal pregnancy were 92%, 86%, 85.7%, and 92.5%, respectively. Conclusion: Serum CPK is considered as a valuable measurement for diagnosis of tubal pregnancy. It is also a useful biomarker in discriminating ruptured from unruptured cases.</p> Keywords: Creatine phosphokinase, Ectopic pregnancy, Intrauterine pregnancy 97 104 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-717&slc_lang=fa&sid=1 Talaat Dabbaghi Gale طلعت دباغی قلعه 5200319475328460059571 5200319475328460059571 No Dept. of Obstetrics & Gynecology, Kosar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran Farideh Movahed فریده موحد 5200319475328460059572 5200319475328460059572 No Dept. of Obstetrics & Gynecology, Kosar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran Fatemeh Samiee Rad فاطمه سمیعی‌راد 5200319475328460059573 5200319475328460059573 No Dept of Pathology, Kosar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran Khadijeh Elmizadeh خدیجه علمی زاده khelmizadeh@qums.ac.ir 5200319475328460059574 5200319475328460059574 Yes Dept. of Obstetrics & Gynecology, Kosar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran hadieh Saghafi هدیه ثقفی 5200319475328460059575 5200319475328460059575 No Dept. of Obstetrics & Gynecology, Kosar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran