fa تاثیر عصاره‌ی هیدرو الکلی کاهو (Lactuca sativa) بر اسپرماتوژنز و هورمون‌های جنسی در موش کوچک آزمایشگاهی کارآزمایی بالینی Clinical Trials <p>Background and Objective: Lettuce (Lactuca sativa) is one of the long-standing herbs in traditional medicine known with many therapeutic properties. In this research, the effect of lettuce leaf extract on some reproductive traits such as testes weight and primary spermatocyte testosterone, LH and FSH in mice was investigated. Materials and Methods: In this experimental study, 40 male mice were selected and were randomly divided into 5 groups, including a control and 3 treatment and placebo groups. Treatment groups of animals received three intraperitoneal lettuce extract in daily doses of 25, 50 and 100 mg/kg for 20 days. Testosterone, LH and FSH tests implemented via Radioimmunoassay (RIA). The collected data analyzed by ANOVA and Duncan&#39;s test. Results: The results showed that the number of secondary spermatocytes (42&plusmn;5) and concentrations of testosterone (0.088&plusmn;0.023 ng/dl), LH (0.3&plusmn;0.02 mIU/dl) and FSH (1&plusmn;0.12 mIU/dl) significantly reduced at 100 mg/kg dose (P<0.05). Conclusion: Considering the results, it seems that the compounds in lettuce extract can exert a negative effect on male mice reproductive physiology as a result of reduction in spermatocytes and reproductive hormones.</p> Keywords: Lactuca sativa, Spermatocytes, Reproductive hormones, Male mice 32 41 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-723&slc_lang=fa&sid=1 Mehrdad Modaresi مهرداد مدرسی mehrdad_modaresi@hotmail.com 5200319475328460059505 5200319475328460059505 Yes Faculty of Agriculture, Dept. of Animal Sciences, Khorasgan Branch, Islamic Azad University, Isfahan, Iran Fereshteh Tavanaei فرشته توانایی 5200319475328460059506 5200319475328460059506 No Dept. of Biology, Payam-e-Noor University, Golpayegan Branch, Isfahan, Iran