fa تاثیر آراشیدونیل سیکلو پروپیل آمید (ACPA) بر یادگیری وابسته به وضعیت موسیمول در مدل یادگیری احترازی غیر فعال در موش سوری کارآزمایی بالینی Clinical Trials <p>Background and Objective: It has been shown that cannabinoids exert widespread effects on cognitive functions. An overlapping distribution of GABA with cannabinoid receptors has been reported in some brain structures such as dorsal hippocampus. Thus, the functional interactions between cannabinoid and GABAergic systems in cognitive control seem possible. The present study evaluated the potential role of cannabinoid CB1 receptors of the dorsal hippocampus on muscimol induced amnesia and muscimol state-dependent memory in adult male mice. Materials and Methods: In this experimental study 250 adult male NMRI mice were entered. Drugs of muscimol and ACPA were used. Mice were anaesthetized and cannulae implantation was bilaterally used in the CA1 regions of the dorsal hippocampus via stereotaxic method. Seven days after recovery from surgery, the behavioral testing was started by means of inhibitory avoidance task. Results: Post-training injection of muscimol (0.075, 0.15 &micro;g/mouse) impaired inhibitory avoidance memory. The memory impairment induced by ACPA (0.15 &micro;g/mouse) was completely reversed by pre-test administration of ACPA and/or muscimol, suggesting muscimol induced state-dependent memory. Conclusion: These results suggest that cannabinoid CB1 receptors of the dorsal hippocampal may play an essential role in muscimol-induced amnesia and muscimol state-dependent memory in mice.</p> Keywords: Muscimol, Arachidonylcyclopropylamide (ACPA), State-dependent memory, Mice 42 53 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-724&slc_lang=fa&sid=1 Bahareh Pakpour بهاره پاکپور 5200319475328460059507 5200319475328460059507 No Dept. of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran Kobra Jafari کبری جعفری 5200319475328460059508 5200319475328460059508 No Dept. of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Zahra Bashiri زهرا بشیری 5200319475328460059509 5200319475328460059509 No Dept. of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Majid Navaeian مجید نوائیان 5200319475328460059510 5200319475328460059510 No Dept. of Biology, Islamic Azad University, Shahr-e-Rey Branch, Shahr-e-Rey, Iran Morteza Piri مرتضی پیری biopiri@yahoo.com 5200319475328460059511 5200319475328460059511 Yes Faculty of Medicine, Dept. of Biology, Islamic Azad University, Ardabil Branch, Ardabil, Iran