fa بررسی شاخص‌های استرس اکسیداتیو در بیماران با تنگی اثبات شده‌ی عروق کرونر و مقایسه با افراد نرمال <pre style="text-align: justify;"> <span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong><em>Background and objective:</em></strong> Cardiovascular disease accounts for about 38% of the cause of death in Iran. The traditional risk factors can not justify the high prevalence of the disease, and therefore oxidative stress has been proposed as a contributing factor in morbidity and mortality. The aim of this study was to evaluate the plasma measures of oxidative stress in patients with CAD presented with myocardial infarction (MI) or without MI compared with the control group. </span></span></pre> <pre style="text-align: justify;"> <span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong><em>Materials and Methods:</em></strong> This study consistsed of three groups as follow: 38 patients suffering from CAD without MI (mean age: 56.55&plusmn;8.64), 20 CAD patients with MI (mean age: 50.85&plusmn;7.79) and 55 healthy subjects (mean age: 49.85&plusmn;8.5) as controls. Vitamin E concentration was determined through HPLC. and the amounts of glutathione and malondialdehyde were measured by spectrophotometer.</span></span></pre> <pre style="text-align: justify;"> <span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong><em>Results:</em></strong> Plasma malondialdehyde levels were markedly higher in patient groups than in control groups (P<0.05). Lower glutathione levels were observed in patient groups compared with control group, whereas, reduced Vitamin E was only noted in CAD patients without MI (P<0.05). No significant differences were seen between measures of oxidative stress in patient groups.</span></span></pre> <pre style="text-align: justify;"> <span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong><em>Conclusion:</em></strong> Reduction of glutathione molecules as antioxidants and enhanced lipid peroxidation may be involved in pathogenesis of CAD through up-regulation of signaling pathways leading to tissue damage. </span></span></pre> Coronary artery disease, Oxidative stress, Vitamin E, Glutathione, Malondialdehyde 47 56 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-76&slc_lang=fa&sid=1 Jafar Nourooz- Zadeh جعفر نوروزاده jnouroozzadeh@yahoo.co.uk 5200319475328460057926 5200319475328460057926 Yes Department of Biochemistry and Nutrition, Urmia University of Medical Sciences, Urmia, Iran. Ebrahim Eftekhar ابراهیم افتخار 5200319475328460057927 5200319475328460057927 No Fariborz Haghparast فریبرز حق پرست 5200319475328460057928 5200319475328460057928 No Kamal Khademwatan کمال خادم وطن 5200319475328460057929 5200319475328460057929 No Mahnaz Ekhlasmand مهناز اخلاصمند 5200319475328460057930 5200319475328460057930 No