Journal of Advances in Medical and Biomedical Research

fa ارزیابی تاثیر هشت هفته فعالیت هوازی بر میزان ویسفاتین، IL-6و TNF-α در موش‌های ماده‌ی نژاد اسپراگوداولی The Effect of Eight Weeks of Aerobic Exercises on Visfatin, IL-6 and TNF-α in Female Sprague Dawley Rats کارآزمایی بالینی Clinical Trials <p>Background and Objective: Adipose tissue is an endocrine organ with the ability to produce and release a variety of cytokines such as free fat acid, leptin, adiponectin, visfatin, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). The purpose of this study was to investigate the probable changes in visfatin, IL-6 and TNF-α on female rats after 8 weeks of intense aerobic exercises. Materials and Methods: This experimental study was conducted on 45 sprague dawley rats with mean age of 2 months and mean weight of 220±20 g. In order to determine the pre-test variables, 15 rats were killed and blood samples were taken from their hearts. Then, the rest of the rats were randomly divided into two groups of control (n=15) and training (n=15). The training group did the exercises 5 days a week for 8 weeks on Rodents' treadmill. Results: There were significant differences in plasma levels of visfatin and IL-6 in training and control groups (P=0.0001). This significant difference was found in the training group rather than the control or pre-test groups (P=0.0001). Furthermore, no significant difference was observed in TNF-α changes between the groups (P<0.05). Conclusion: Exercise has the potential to decrease visfatin plasma levels and bring about changes in the expression of inflammatory cytokines. Therefore, it can be stated that the training program may prevent and improve inflammatory diseases, obesity, diabetes and insulin resistance.</p> Keywords: Aerobic exercise, Interleukin-6, Necrosis factor of alpha tumor, Visfati 30 39 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-747&slc_lang=fa&sid=1 Firouz Soltani فیروز سلطانی 5200319475328460059421 5200319475328460059421 No Dept. of Sport Physiology, School of Physical Education and Sport Sciences, Shiraz University, Shiraz, Iran Farhad Daryanoosh فرهاد دریانوش Daryanoosh@shirazu.ac.ir 5200319475328460059422 5200319475328460059422 Yes Dept. of Sport Physiology, School of Physical Education and Sport Sciences, Shiraz University, Shiraz, Iran Mohsen Salesi محسن ثالثی 5200319475328460059423 5200319475328460059423 No Dept. of Sport Physiology, School of Physical Education and Sport Sciences, Shiraz University, Shiraz, Iran Mehdi Mohamadi مهدی محمدی 5200319475328460059424 5200319475328460059424 No Dept. of Educational Administration, Shiraz University, Shiraz, Iran Hosein Jafari حسین جعفری 5200319475328460059425 5200319475328460059425 No Dept. of Sport Physiology, School of Physical Education and Sport Sciences, Shiraz University, Shiraz, Iran Amin Soltani امین سلطانی 5200319475328460059426 5200319475328460059426 No Dept. of Sport Physiology, School of Physical Education and Sport Sciences, Shahid Cnamran University, Ahvaz, Iran