fa اثر آمیگدالین بر درد ناشی از فرمالین در موش‌های سوری نر کارآزمایی بالینی Clinical Trials <p>Background and Objective: Amygdalin is likely to have analgesic and metabolic effects. In this study, the effects of chronic administration of amygdalin were investigated on the pain threshold, weight and blood sugar of mice. Materials and Methods: In this experimental study, formalin test was used as a chronic inflammatory model of pain. 60 mice (30-35 g) were divided into four groups (n=15) including: control and amygdalin 10, 25 and 50 mg /kgw groups. Amygdalin was solved in saline and injected intraperitoneally every day at 9-10am. The control group received saline intraperitoneally for one week. After the last treatment, 40&micro;l formalin (2.5%) was injected to the right hind paw of the mice and pain symptoms (frequency of collecting flinching of the back skin and licking injection site) were recorded for 60 min. Weight of the mice was measured before and after the last treatment with amygdalin. Blood glucose was also measured at the end of the experiment. Results were analyzed by using one way ANOVA and Tukey or paired t-test. Results: Intraperitoneal injection of 10, 25 and 50 mg/kgw doses of amygdalin reduced pain in male mice. In concentration of 50 mg/kg, not only the pain was completely inhibited but the animals&rsquo;weight also decreased compared to pre-treatment period. Chronic injections of amygdalin had no impact on normal blood sugar levels. Conclusion: Chronic intraperitoneal injection of amygdalin increases pain threshold in mice and may also cause weight loss.</p> Keywords: Amygdalin, Formalin test, Pain, Mice 85 94 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-752&slc_lang=fa&sid=1 Nematollah Gabaei نعمت اله غیبی 5200319475328460059440 5200319475328460059440 No Dept. of Biophysics, Qazvin University of Medical Sciences, Qazvin, Iran Mohammad Sofiabadi محمد صوفی آبادی mohasofi@yahoo.com 5200319475328460059441 5200319475328460059441 Yes Dept. of Physiology, Qazvin University of Medical Sciences, Qazvin, Iran Hasan Azhdari Zarmehri حسن اژدری زرمهری 5200319475328460059442 5200319475328460059442 No Dept. of Physiology, Qazvin University of Medical Sciences, Qazvin, Iran Mohammad hosein Esmaeili محمدحسین اسماعیلی 5200319475328460059443 5200319475328460059443 No Dept. of Physiology, Qazvin University of Medical Sciences, Qazvin, Iran Shahram Rastak شهرام رستاک 5200319475328460059444 5200319475328460059444 No Faculty of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran Leila Daragi لیلا درگی 5200319475328460059445 5200319475328460059445 No Faculty of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran Hamid Rasolpour حمید رسول پور 5200319475328460059446 5200319475328460059446 No Faculty of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran