fa تاثیر ترکیب جدیدی از فنانترولین بر میزان تستوسترون و اثرات ضد باروری آن در موش های نر بالغ نژاد Balb/C مقاله پژوهشی Original Research Article <div style="text-align: justify;"><strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Background:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> Due to the problems arising from the overpopulation, attention has been focused on contraceptives for men. Phenanthrolines are a group of organic compounds with ionophilic characteristics and a wide range of use in biology and chemistry. In this study the effect of 2,6-diaminopyridinum was studied on hypophysis-gonad axis, testicular tissue and sperm production in male Balb/c mice. </span></span><br> <span style="color:#ffffff;"><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="background-color:#16a085;">Materials and Methods:</span></span></span></span><span style="font-size:16px;"><span style="font-family:Times New Roman;"> Fifty adult male Balb/C mice were divided in 5 groups. First group was used as untreated control. Saline was injected to the 2nd group and the remaining 3 groups were received intraperitoneal injection of 15, 20 and 25 mg/kg of 2,6-diaminopyridinum every other day for 20 days. The LD50 was determined to be 35 mg/kg body weight. The serum concentrations of FSH, LH and testosterone were measured and the testicular tissues were studied morphologically.</span></span><br> <span style="color:#ffffff;"><span style="font-size:18px;"><span style="font-family:Times New Roman;"><strong><span style="background-color:#16a085;">Results:</span></strong></span></span></span><span style="font-size:16px;"><span style="font-family:Times New Roman;"> The data showed that 25 mg/kg diaminopyridinum decreased the serum testosterone level significantly with no changes on FSH and LH levels. Histological studies on testicular tissue showed a significantly lower numbers of germ cells.</span></span><br> <strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> The data obtained in this study indicate that 25 mg/kg of phenanthroline may directly affect testicular tissue causing a lower testosterone level and spermatogenesis in mice.</span></span></div> PHENANTHROLINE, HYPOPHYSIS-GONAD AXIS, TESTICULAR TISSUE, SPERMATOGENESIS 9 15 http://journal.zums.ac.ir/browse.php?a_code=A-10-1-30&slc_lang=fa&sid=1 Mehrdad Shariati مهرداد شریعتی 5200319475328460070038 5200319475328460070038 Yes Kazem Parivar کاظم پریور 5200319475328460070039 5200319475328460070039 No Shahrbano Oryan شهربانو عریان 5200319475328460070040 5200319475328460070040 No Abbas Shokravi عباس شکروی 5200319475328460070041 5200319475328460070041 No Robabeh Alizadeh ربابه علی زاده 5200319475328460070042 5200319475328460070042 No