fa افزایش رهایی کورتیکوسترون پلاسما با تزریق ممانتین به داخل هسته اکومبنس در موش‌های کوچک آزمایشگاهی ماده نژاد NMRI کارآزمایی بالینی Clinical Trials <p dir="ltr" style="text-align: justify"><strong><em>Background and Objective:</em></strong> Memantine is a glutamate N-Methyl-D-Aspartate (NMDA) receptor antagonist with low receptor binding affinity which is currently used in moderate to severe Alzheimer&rsquo;s disease. So far, the effect of memantine on stress system has not been investigated. This study focused on the effects of both peripheral and intra-accumbal memantine administration on plasma corticosterone concentration in female NMRI mice.</p> <p dir="ltr" style="text-align: justify"><strong><em>Materials and Methods:</em></strong> Four groups of mice (n=6/group) received different doses of memantine (1, 0.5 and 0.1 mg/kg) intraperitoneally. In this groups were canulated bi- or unilaterally in the nucleus accumbens by stereotaxic instrument. After a week of recovery, memantine (1, 0.5 and 0.1 &micro;g/kg mouse) was administrated to the animals intra-accumbally. Blood samples were taken from retro-orbital sinus of all animals 30 min (intraperitoneally administration) or 5 min (intra-accumbally) following memantine injection for the evaluation of plasma corticosterone.</p> <p dir="ltr" style="text-align: justify"><strong><em>Results:</em></strong> Intraperitoneal memantine injection led to a dramatic increase in plasma corticosterone concentration in a dose-independent manner. On the other hand, intra-accumbal memantine administrations increased plasma corticosterone level significantly (P<0.001) in a dose and site &ndash;dependent manner.&nbsp;</p> <p dir="ltr" style="text-align: justify"><strong><em>Conclusion:</em></strong> Memantine may have a severe effect on stress system by virtue of plasma corticosterone level increment which may be the side effect of this medication.</p> <p></p> Keywords: Memantine, Nucleus Accumbens, Plasma Corticosterone, Stress 55 65 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-903&slc_lang=fa&sid=1 Homeir Zardooz حمیرا زردوز 5200319475328460058840 5200319475328460058840 No Dept. of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. دانشگاه علوم پزشکی شهید بهشتی Nahid Sarahian ناهید سراحیان sarahiannahid@yahoo.com 5200319475328460058841 5200319475328460058841 Yes Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran. دانشگاه علوم پزشکی بقیه الله Hedayat Sahraei هدایت صحرایی 5200319475328460058842 5200319475328460058842 No Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran. دانشگاه علوم پزشکی بقیه الله Bahareh Sadeghi بهاره صادقی 5200319475328460058843 5200319475328460058843 No Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran. دانشگاه علوم پزشکی بقیه الله