fa اثر عصاره‌ی هیدرواتانولی گیاه پنیرک (Malva silvestris L.) بر تشنج ناشی از تزریق وریدی پنتیلن تترازول در موش‌های سوری نر کارآزمایی بالینی Clinical Trials <div dir="ltr"> <p style="margin-right: -2.3pt text-align: justify"><strong><em>Background and Objective:</em></strong> <em>Malva silvestris</em> (Malvaceae), which is used in traditional medicine has antioxidant and anti-inflammatory activity. The effects of this plant on clonic seizure have not yet been studied. The present study evaluated the anticonvulsant effect of <em>M. silvestris</em> in a model of clonic seizures induced with pentylenetetrazole (PTZ) on male mice.</p> <p style="margin-right: -2.3pt text-align: justify"><strong><em>Materials and Methods:</em></strong> In this experimental study the anticonvulsant effect of <em>M. silvestris</em> was investigated using <em>i.v</em> PTZ-induced seizure models on mice. Different doses of the hydroethanolic extract of <em>M. silvestris</em> (150 and 300 mg/kg) were administered intraperitonally 2 hours before the &nbsp;induction of PTZ. The effect of <em>M. silvestris</em> on the appearance of three separate seizure endpoints including myoclonic, generalized clonus and forelimb tonic extension phase was recorded. Differences were considered significant at p <0.05.</p> <p style="margin-right: -2.3pt text-align: justify"><strong><em>Results:</em></strong> The results showed that the <em>M. silvestris</em> extract had anticonvulsant effects on all the experimental treatment groups and significantly increased the seizure threshold. Hydroethanolic extract of <em>M. silvestris</em> significantly increased the onset time of myoclonic seizure (p<0.001) and increased the threshold for the forelimb tonic extension seizure (p<0.01) compared with the control group. But it did not show any significant effect on generalized clonic phase response.</p> <p style="margin-right: -2.3pt text-align: justify"><strong><em>Conclusion:</em></strong> The results of the present study imply that injection of hydroethanolic extracts of <em>M. silvestris</em> led to anticonvulsant activity in <em>i.v.</em> PTZ-induced seizure in male mice.</p> <p></p></div> Keywords: Epilepsy, Seizure, Malva silvestris, Pentylenetetrazole, Mice 98 107 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-907&slc_lang=fa&sid=1 Naser Mirazi ناصر میرازی mirazi@basu.ac.ir 5200319475328460058851 5200319475328460058851 Yes Dept. of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan, Iran. دانشگاه بوعلی سینا همدان Soheileh Shamohammadi سهیله شامحمدی 5200319475328460058852 5200319475328460058852 No Dept. of Biology, Faculty of Basic Sciences, Islamic Azad University ,Hamedan Branch, Hamedan, Iran دانشگاه آزاد اسلامی واحد همدان Abdol karim Hosseini عبدالکریم حسینی 5200319475328460058853 5200319475328460058853 No Dept. of Biology, Faculty of Basic Sciences, Islamic Azad University ,Hamedan Branch, Hamedan, Iran دانشگاه شهید بهشتی تهران