fa سرواپیدمیولوژی HTLV1 در بیماران با تالاسمی ماژور شهرهای زابل و زاهدان مقاله پژوهشی Original Research Article <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:16px;"><strong><span style="color:#ffffff;"><span style="background-color:#16a085;">Background:</span></span></strong> Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of several disorders including adult T-cell leukemia, HTLV-1-associated myelopathy and tropical spastic paralysis. HTLV-1 can be transmitted through different routes such as: blood transfusion, needle sharing, breast-feeding and heterosexual intercourse. This study was carried out to detect HTLV-1 antibody in patients with thalassemia major as a high-risk group versus healthy individuals in the cities of Zahedan and Zaboul in 2001.</span><br> <strong><span style="font-size:18px;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span></span></strong><span style="font-size:16px;"> This historical cohort study was conducted on 379 individuals (190 sufferers of B-thalassemia and 189 healthy persons) from cities of Zahedan and Zaboul. 3ml peripheral blood was collected from each person. Sera were separated and ELISA was used to detect anti-HTLV-1 antibody. In positive samples, the virus type was determined by Western blotting. The results were statistically analysed by student&#39;s t-test.</span><br> <strong><span style="font-size:18px;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></span></strong><span style="font-size:16px;"> Antibodies against HTLV-1 were detected in 1.6% of thalassemic patients and 0.5% of control group. None of the positive individuals were received blood from Khorasan province and there were no relationship among age, sex, family relation between father and mother, thalasemic patient in the family and history of travel to Khorasan province with HTLV-1. Conclusion: The results indicated that the main route of HTLV-1 infection in Iran is probably blood transfusion. Therefore, it is recommended that all the blood donors be screened for HTLV-1 in order to prevent viral infection.</span></span></div> HTLV-1, THALASSEMIA, BLOOD TRANSFUSION 43 49 http://journal.zums.ac.ir/browse.php?a_code=A-10-1-113&slc_lang=fa&sid=1 Abdolvahab Moradi عبدالوهاب مرادی 5200319475328460070078 5200319475328460070078 No Zohre Yaghoubnezhad زهره یعقوب نژاد 5200319475328460070079 5200319475328460070079 No Amirhossein Mohagheghi امیرحسین محققی 5200319475328460070080 5200319475328460070080 No Shahram Shahraki شهرام شهرکی 5200319475328460070081 5200319475328460070081 No Abasalt Borji اباصلت برجی 5200319475328460070082 5200319475328460070082 No Mohammadreza Firouzkouhi محمدرضا فیروزکوهی 5200319475328460070083 5200319475328460070083 No Ebrahim Mirimoghadam ابراهیم میری مقدم 5200319475328460070084 5200319475328460070084 Yes Malek Rakhshani مالک رخشانی 5200319475328460070085 5200319475328460070085 No Esmaeil Saneimoghadam اسماعیل صانعی مقدم 5200319475328460070086 5200319475328460070086 No