fa ارتباط بین سطح ویتامینE مایع فولیکولی با مورفولوژی تخمک و کیفیت جنین در بیماران IVF در بیمارستان الزهرا (س) رشت کارآزمایی بالینی Clinical Trials <div> <p><strong><em>Background and Objective:</em></strong> As a result of globally increasing trend in infertility, taking advantage of reproductive technology to deal with this issue is recommended. Taking the well-founded claim about Vitamin E as a powerful antioxidant with a protective role in the body, this study was instigated to find the relationship between levels of vitamin E in Follicular fluid and morphology of <a name="OLE_LINK4"></a><a name="OLE_LINK3">oocyte</a> along with embryo quality in IVF patients.</p> <p><strong><em>Materials and Methods:</em></strong> This cross-sectional analytical study was carried out on oocytes and embryos obtained from 50 women with IVF admitted to Al Zahra Hospital of Rasht city. Patients underwent a similar ovulation stimulation protocol and then ten thousand units of hCG injected. After 36 hours, they underwent Follicle suction and mature oocytes were isolated for fertilization. Vitamin E level was measured and consequently the morphology of oocytes and the quality of embryo were evaluated by means of inverted optical microscopy.</p> <p><strong><em>Results:</em></strong> Of 50 treated IVF women, 583 oocytes and 275 embryos were examined. No significant relationship was observed between age, BMI, duration or cause of infertility and Vitamin E (P>0/05). At 0.5-1 mg/dl level of vitamin E, there were higher MII oocytes in comparison with other levels (p= 0.014). Despite the mean number of 2PN embryos at this level of vitamin E was more than other levels, this difference was not statistically significant (P=0.872).</p> <p><strong><em>Conclusion:</em></strong> The results prove the evidence that at 0.5-1mg/dl level of Vitamin E, oocyte morphology and embryo quality were significantly improved.</p> <p></p><p></p><p></p>&nbsp; <p></p> <p></p></div> <p style="margin-left:18.0pt"></p><p style="margin-left:18.0pt"></p><p align="center"></p><p align="center"></p><p style="margin-left:3.5pt"></p> <div><p></p></div> <p></p> Keywords: Infertility, Follicular Fluid, IVF, Vitamin E, Oocytes, Embryo, Antioxidants 21 31 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-912&slc_lang=fa&sid=1 Safoura Saffari صفورا صفاری 5200319475328460053872 5200319475328460053872 No Dept.of Biology, Karaj Branch, Islamic Azad University , Karaj, Iran. دانشگاه آزاد اسلامی واحد کرج Mohammad Hadi Bahadori محمد هادی بهادری bahadori.mh@gmail.com 5200319475328460053873 5200319475328460053873 Yes Dept .of Anatomical Sciences, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. دانشگاه علوم پزشکی گیلان Seyed Hajar Sharami سیده هاجر شارمی 5200319475328460053874 5200319475328460053874 No Al-Zahra Reproductive Health Research Center, Guilan University of Medical Sciences, Rasht, Iran. دانشگاه علوم پزشکی گیلان Parvin Torab Zadeh پروین تراب‌زاده 5200319475328460053875 5200319475328460053875 No Dept.of Biology, Karaj Branch, Islamic Azad University , Karaj, Iran. دانشگاه آزاد اسلامی واحد کرج Mahdi Goudarzvand مهدی گودرزوند 5200319475328460053876 5200319475328460053876 No Dept.of Physiology Alborz University of Medical Sciences, Karaj, Iran دانشگاه علوم پزشکی البرز