fa ارزشیابی سطح حساسیت کک انسان (Pulex Irritans) نسبت به پیرتروئیدها کارآزمایی بالینی Clinical Trials <div><p></p></div> <p><strong><em>Background and Objective</em></strong><strong>:</strong> Human flea is assumed as the most dominant ectoparasite associated with transmitting diseases via biting humans. Insecticides are widely employed to curb this vector. Assessment of susceptibility level of populations to various pesticides is necessary for taking appropriate control measures.</p> <p><strong><em>Materials and Methods</em></strong><strong>:</strong> Subsequent to collection of human flee from indoor areas of Khodabandeh and Mahneshan located in Zanjan province from August 2013 to November 2014, they were kept under standard laboratory conditions. The samples were exposed to inconsistent doses of Permethrin and Lambdacyhalothrin and consequently their mortality rates were assessed after 24 hours.</p> <p><strong><em>Results:</em></strong> Out of 1074 collected fleas, 88.1% were <em>Pulex irritans</em>, 7.2% <em>Ctenocephalides cani </em>and 4.7%<em> C. felis. </em><a>Bioassay</a><a href="#_msocom_1" id="_anchor_1">[s1]</a>&nbsp; results gave evidence to homogeneity of study population. LD₅₀ values for permethrin and lambdacyhalothrin were 288.40 &ndash; 295.15 &micro;g/ cm² and 21.87 &ndash; 24.54 &micro;g/cm^2, respectively.</p> <p><strong><em>Conclusion</em></strong>: High levels of LD₅₀ values to pyrethroides of human flea in the studied area indicated the requirement of more attention of health workers to control the vector and <a>Further</a><a href="#_msocom_2" id="_anchor_2">[s2]</a>&nbsp;&nbsp; research is necessary to assess the resistance status of human flea to alternative effective insecticides.</p> <p></p><p></p> Keywords: Pulex irritanse, Permethrin, Lambdacyhalothrin, Bioassay 80 89 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-915&slc_lang=fa&sid=1 Fahimeh Pourrastgou Haghi فهیمه پورراستگوی حقی 5200319475328460057369 5200319475328460057369 No Dept. of Medical Entomology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Mohammad Bagher Ghavami محمدباقر قوامی Ghavami@zums.ac.ir 5200319475328460057370 5200319475328460057370 Yes Dept. of Medical Entomology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Jamshid Mohammadi جمشید محمدی 5200319475328460057371 5200319475328460057371 No دانشگاه علوم پزشکی زنجان Behrouz Taghiloo بهروز تقی لو 5200319475328460057372 5200319475328460057372 No Zanjan Health Center, Zanjan University of Medical Sciences, Zanjan, Iran. دانشگاه علوم پزشکی زنجان Habibeh Mirzadeh حبیبه میرزاده 5200319475328460057373 5200319475328460057373 No Dept. of Medical Entomology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان