fa مقایسه‌ی اثرات ترکیبی چای سبز و آویشن شیرازی در یادگیری احترازی غیرفعال و نوروژنز هیپوکامپ در رت‌های نر نژاد ویستار کارآزمایی بالینی Clinical Trials <p><strong><em>Background and Objective:</em></strong> Antioxidants along with other active biological effects of <em>Green Tea </em>and<em> Zataria multiflora boiss</em> deserve paramount consideration. This study was an attempt to evaluate the effects of <em>Green Tea </em>and<em> Zataria multiflora boiss</em> on passive avoidance learning and hippocampus neurogenesis in Wister male rats.</p> <p><strong><em>Materials and Methods</em></strong><strong>:</strong> Upon assigning the rats to three groups of control (intact), sham and experimental, the sham group received 1 cc of distilled water by infusion for 8 weeks, whereas the experimental group received 0.5 cc of green tea and 0.5 cc of <em>Zataria multiflora boiss</em> infusion, with concentration of 0.04 g/ml via oral gavage daily for 8 weeks. Subsequent to administration of behavioral test (Passive avoidance learning), density of neurons in the rats&rsquo; hippocampus was microscopically assessed and one-way ANOVA test was implemented for data analysis.</p> <p><strong><em>Results</em></strong><strong>:</strong> <em>Green tea </em>and<em> Zataria multiflora boiss</em> significantly enhanced memory recall in animals. In the meantime, over histologic analysis, augmentation in the number of neurons in the hippocampus regions was observed.</p> <p><strong><em>Conclusion</em></strong><strong>:</strong> These findings verify the beneficial remedial effects of<em> green tea </em>and<em> Zataria multiflora boiss</em> on improvement of memory, neurogenesis of CA3 regions and dentate gyrus in rat hippocampus.&nbsp;</p> <p></p><p></p> Keywords: Neurogenesis, Green Tea and zataria multiflora boiss, Passive avoidance learning 57 67 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-921&slc_lang=fa&sid=1 Parisa Hassani پریسا حسنی 5200319475328460057361 5200319475328460057361 No Dept. of Developmental Cell, Islamic Azad University, Karaj Branch, Karaj, Iran. دانشگاه آزاد اسلامی واحد علوم و تحقیقات تهران Parichehr Yaghmaei پریچهره یغمایی yaghmaei_p@yahoo.com 5200319475328460057362 5200319475328460057362 Yes Dept. Cellular and Molecular Biology, Faculty of Life Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran. دانشگاه آزاد اسلامی واحد علوم و تحقیقات تهران Nasim Hayati Roodbari نسیم حیاتی رودباری 5200319475328460057363 5200319475328460057363 No Dept. of Developmental Cell, Islamic Azad University, Karaj Branch, Karaj, Iran. دانشگاه آزاد اسلامی واحد علوم و تحقیقات تهران