fa بررسی اثر قرارگیری طولانی مدت در معرض امواج الکترومغناطیس با فرکانس فوق‌العاده پایین بر فعالیت سیستم نیتررژیک در روده‌ی باریک موش صحرایی نر کارآزمایی بالینی Clinical Trials <p><a name="OLE_LINK10"></a><a name="OLE_LINK9"><strong><em>Background and Objective</em></strong></a>: Nitric Oxide in the small intestine causes relaxation of smooth muscles. Research indicates that extremely low frequency electromagnetic fields (ELF) affect nitric oxide level in the tissues. The objective of this study was to grasp the effect of prolonged exposure to ELF on the nitrergic system in the small intestine<span dir="RTL">.</span></p> <p><strong><em>Materials and Methods</em></strong><strong>:</strong> 21 adult male rats were allocated to three groups: the experimental group exposed to ELF (50Hz, 1mT) for 75 days, the sham-operated group underwent similar conditions except ELF exposure; and the control group mice were kept under the laboratory normal condition. The isolated strips of the colon were inserted into organ bath and were linked to force transducer power lab A to D system and their mechanical activity were recorded in response to L-NAME. Data was analyzed using one way ANOVA test.</p> <p><strong><em>Results</em></strong>: The results exhibited a significant increase (p&le;0.05) of ileum basal contractions in experimental group when compared to control and sham groups. However, administration of L-NAME (inhibitor of NO synthesis) led to a significant decrease in ileum contraction in the experimental group compared to the sham and control groups (p&le;0.05).</p> <p><strong><em>Conclusion</em></strong>: It can be concluded that prolonged exposure to extremely low-frequency electromagnetic fields may decrease the activity of nitrergic system in small intestine of the male rats<span dir="RTL">.</span></p> <p></p><p></p> Keywords: Electromagnetic fields, Nitric oxide, Ileum 94 101 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-944&slc_lang=fa&sid=1 Marziyeh Jafari مرضیه جعفری 5200319475328460053764 5200319475328460053764 No Dept. of Biology, Faculty of Sciences, Shiraz University , Shiraz, Iran دانشگاه شیراز Aminollah Bahaoddini امین‌الله بهاالدینی 5200319475328460053765 5200319475328460053765 No Dept. of Biology, Faculty of Sciences, Shiraz University , Shiraz, Iran دانشگاه شیراز Seyed Esmaeil Khoshnam سید اسماعیل خوشنام esmaeil.khoshnam1392@gmail.com 5200319475328460053766 5200319475328460053766 Yes Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran دانشگاه علوم پزشکی جندی شاپور اهواز Maryam Owjfard مریم اوج فرد 5200319475328460053767 5200319475328460053767 No Dept. of Biology, Faculty of Sciences, Shiraz University , Shiraz, Iran دانشگاه علوم پزشکی جندی شاپور اهواز