fa اثر عصاره‌ی هیدرو الکلی گیاه تشنه‌داری (Scrophularia striata Boiss.) بر کاهش درد با استفاده از آزمون فرمالین در موش سوری کارآزمایی بالینی Clinical Trials <p><strong><em>Background and Objective:</em></strong> Nowadays, a wide variety of chemical agents are used to mitigate the pain, whereas all of them are associated with complications.<em> Scrophularia striata Boiss</em> that grows in the area of Ilam in Iran has been experimentally used in the treatment of various diseases. However, there is a lack of research on this plant. This study was an endeavor to elucidate the effect of hydro-alcoholic extract of <em>Scrophularia striata</em> Boiss on formalin-induced pain.</p> <p><strong><em>Materials and Methods:</em></strong> In this study, 40 male mice (25-30 g) were randomly selected and divided into five groups of 8 including &nbsp;a control group (receiving saline) along with 4 treatment groups (receiving the extract doses of 150, 300, 600 and 900 mg/kg). 30 minutes after IP administration with saline (in the control group), and different doses of extract (in the treatment groups), animals were immediately transferred to a special cage and after formalin injection in their paw skin, induced pain behaviors were recorded for 60 minutes.</p> <p><strong><em>Results:</em></strong> As the dosage of extract increased, significant reductions were seen in phases 1 and 2 in the treatment groups rather than control group. But, there was not any change in interphase. Extract administration with doses of 150, 300, 600 and 900 mg/kg caused significant reduction in nociceptive behaviors in the first phase of formalin test. Also, this decreasing pattern was seen in phase 2 in 600 and 900 mg/kg treatment groups. Despite an evident decrease in nociceptive behaviors in the interphase, it was nonsignificant.</p> <p><strong><em>Conclusion:</em></strong> This study illustrates that <em>Scrophularia striata Boiss </em>hydroalcoholic extract has analgesic properties on formalin test in mice.</p> <p style="margin-left:-27.35pt;"></p><p></p> Keywords: Scrophularia striata Boiss, Hydroalcoholic extract, Formalin test, Mice 78 87 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-954&slc_lang=fa&sid=1 Benyamin Alimohammadi بنیامین علی محمدی 5200319475328460053502 5200319475328460053502 No Dept. of Nursing, Faculty of Nursing, Qazvin University of Medical Sciences, Qazvin, Iran دانشگاه علوم پزشکی قزوین Ramin Mohammadi رامین محمدی 5200319475328460053503 5200319475328460053503 No Dept. of Operating Room, Faculty of Paramedical, Qazvin University of Medical Sciences, Qazvin, Iran دانشگاه علوم پزشکی قزوین Samad Nazemi صمد ناظمی 5200319475328460053504 5200319475328460053504 No Cellular and Molecular Research Center, Faculty of Medicine, Sabzevar University of Medical Sciences, ‎Sabzevar, Iran دانشگاه علوم پزشکی سبزوار Hasan Azhdari Zarmehri حسن اژدری زرمهری hasan.azhdari@gmail.com 5200319475328460053505 5200319475328460053505 Yes Nerouscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran دانشگاه علوم پزشکی تربت حیدریه