fa اثر محافظتی دوزهای مختلف کانابیدیول بر میزان نفوذپذیری سد خونی– مغزی و آسیب‌های حاصل از مدل ایسکمی مغزی در موش صحرایی کارآزمایی بالینی Clinical Trials <p><strong><em>Background and Objective</em></strong><span dir="RTL">:</span> Stroke is a neurological disease with a rapid increase in incidence across developing world<span dir="RTL">.</span> Cannabidiol is a non- psychoactive constituent of <em>cannabis</em> which has attracted the attention of investigators in basic and therapeutic research. The most significant property of cannabidiol is its strong neuroprotective effect manifested in animal model of epilepsy, Alzheimer, and Parkinson. The present study was designed to examine the effect of cannabidiol on stroke damages in particular the blood-brain barrier integrity.</p> <p><strong><em>Materials and Methods</em></strong><span dir="RTL">:</span> 66 rats were randomly divided into 6 main groups<span dir="RTL">.</span> Using stereotaxic surgery, guide cannula was implanted in the lateral ventricle. Cannabidiol (50, 100, and 200 ng) was administrated for 5 consequent days through Intracerebroventricular (i.c.v.) injection. After pretreatment, the rats were subjected to right middle cerebral artery occlusion (MCAO). After 24 hours, reperfusion neurological deficit scores (NDS), infarct volume (IV), and blood&ndash;brain barrier (BBB) permeability were assessed.</p> <p><strong><em>Results</em></strong>: The results indicate that administration of cannabidiol (100 and 200 ng) in the cerebral ischemia caused a remarkable reduction in NDS and IV, as well as BBB permeability in comparison with the vehicle group.</p> <p><strong><em>Conclusion</em></strong>: The obtained results indicate that cannabidiol possibly ameliorates ischemic injuries manifested as infarction through reduction of the blood-brain barrier permeability and neurological defects.</p> <p></p><p></p> Keywords: Cannabidiol, Cerebral ischemia, Infarction, Blood-brain barrier 63 78 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-965&slc_lang=fa&sid=1 Sepideh Khaksar سپیده خاکسار 5200319475328460053429 5200319475328460053429 No Dept. of Physiology, Faculty of Biological Sciences, Shahid Beheshti University,Tehran,Iran دانشگاه شهید بهشتی Mohammadreza Bigdeli محمدرضا بیگدلی bigdelimohammadreza@yahoo.com 5200319475328460053430 5200319475328460053430 Yes Dept. of Physiology, Faculty of Biological Sciences, Shahid Beheshti University,Tehran,Iran دانشگاه شهید بهشتی