fa بررسی اثر درشت مغذی ها بر پاسخ های قلبی - عروقی متابولیک در افراد دیابتی نوع II مقاله پژوهشی Original Research Article <div style="text-align: justify;"><span style="color:#ffffff;"><span style="font-size:18px;"><span style="font-family:Times New Roman;"><strong><span style="background-color:#16a085;">Background:</span></strong></span></span></span><span style="font-size:16px;"><span style="font-family:Times New Roman;"> Information regarding the effects of macronutrients on metabolic and hemodynamic responses in type 2 diabetes mellitus patients is lacking, however, we have information about these responses in healthy subjects. Therefore, this study was designed to explore the effects of macronutrients in diabetics at Shaheed Beheshti University in 2001.</span></span><br> <span style="color:#ffffff;"><span style="font-size:18px;"><span style="font-family:Times New Roman;"><strong><span style="background-color:#16a085;">Materials and Methods:</span></strong></span></span></span><span style="font-size:16px;"><span style="font-family:Times New Roman;"> This clinical trial was carried out on 15 patients with type 2 DM. Insulin and norepinephrine responses were determined before and 15, 30, 60, 90, 120 and 180 minutes after the intake of the wheat starch, sodium caseinat and olive oil while cardiovascular responses such as cardiac output, heart rate, stroke volume and systolic blood pressure measured before and 15, 30, 60, 90 and 120 minutes after these macronutrients. Statistical analyses were done by analysis of variance with repeated measures, independent and dependent t-test. Pearson linear correlations of the responses were used to establish any relationship between cardiovascular and metabolic responses.</span></span><br> <span style="color:#ffffff;"><span style="font-size:18px;"><span style="font-family:Times New Roman;"><strong><span style="background-color:#16a085;">Results:</span></strong></span></span></span><span style="font-size:16px;"><span style="font-family:Times New Roman;"> The mean age of patients (4 women and 11 men) was 38.9 &plusmn; 5.2 year and their the mean of body mass index was 24&plusmn;106 kg/m2. Insulin increased significantly following intake of carbohydrate and protein (p<0.05). Insulin changes were not significant after fat intake. Norepinephrine increased significantly following intake of carbohydrate, protein and fat (P<0.05). Post-prandial cardiac output rose only after protein intake (P=0.004). Systolic blood pressure fell after the ingestion of the macronutrients but, it was significant only after the intake of the fat (P=0.003).</span></span><br> <span style="color:#ffffff;"><span style="font-size:18px;"><span style="font-family:Times New Roman;"><strong><span style="background-color:#16a085;">Conclusion:</span></strong></span></span></span><span style="font-size:16px;"><span style="font-family:Times New Roman;"> There were significant differences between all patients for their cardiovascular and metabolic responses after the intake of carbohydrate, protein and fat. For more conclusive data, we recommend more investigations on a larger group of subjects.</span></span></div> MACRONUTRIENTS, METABOLIC RESPONSES, HEMODYNAMIC RESPONSES, DIABETES MELLITUS TYPE 2 9 16 http://journal.zums.ac.ir/browse.php?a_code=A-10-1-40&slc_lang=fa&sid=1 Fatemeh Kaseb فاطمه کاسب 5200319475328460070089 5200319475328460070089 Yes Masoud Kimiagar مسعود کیمیاگر 5200319475328460070090 5200319475328460070090 No Mohammad Hosein Soltani محمدحسین سلطانی 5200319475328460070091 5200319475328460070091 No Mostafa Hoseini مصطفی حسینی 5200319475328460070092 5200319475328460070092 No