fa بررسی دخالت گیرنده‌ی 1 اورکسین در محرومیت غذایی حاد روی رفتارهای دردی ناشی از آزمون صفحه‌ی داغ در موش بزرگ آزمایشگاهی نر کارآزمایی بالینی Clinical Trials <p><strong><em>Background and Objective:</em></strong> Food deprivation increases the expression of orexin-1 receptor gene in the hypothalamus. On the other hand, food deprivation induces analgesia and orexin has a fundamental and well known role in pain modulation. This study aimed to determine the role of orexin receptor 1 antagonist in analgesic effect of acute food deprivation (12 h) by hot plate test in male rats.</p> <p><strong><em>Materials and Methods:</em></strong> Male Wistar rats were divided into 5 groups (n=8), control, food deprivation without surgery, stereotaxic surgery with vehicle, vehicle and food deprivation and food deprivation and orexin receptor 1 antagonist groups. 12 hours before the hot plate test, food was removed from the animals&rsquo; proximity, but water was freely available. All groups were tested using the hot plate. Data were analyzed statistically by one-way ANOVA with Tukey post hoc test.</p> <p><strong><em>Results:</em></strong> According to our findings, orexin receptor 1 antagonist injection increased pain related behaviors at the time of 5(P<0.05), 15(P<0.05), 30(P<0.01) and 60(P<0.001) minutes in the hot plate test.</p> <p><strong><em>Conclusion</em></strong>: Orexin plays an important role in feeding state&ndash;<a name="hit14"></a>induced pain modulation. Based on our results, change in pain behavior induced by food deprivation may be related to change in orexin expression or in orexin receptors density.</p> <p></p><p></p> Keywords: Food Deprivation, Orexin, SB-334867, Hot Plate, Rat 1 10 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-995&slc_lang=fa&sid=1 Nima Heidari Oranjaghi نیما حیدری اورنجقی 5200319475328460053386 5200319475328460053386 No Dept. of Physiology and Pharmacology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Hassan Azhdari Zarmehri حسن اژدری زرمهری 5200319475328460053387 5200319475328460053387 No Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran دانشگاه علوم پزشکی تربت حیدریه Elmira Ghasemi Dashkasan المیرا قاسمی داشکسن 5200319475328460053388 5200319475328460053388 No Dept. of Physiology and Pharmacology, Tarbiat Modares University, Tehran, Iran دانشگاه تربیت مدرس تهران Mahin GanJKhani مهین گنج خانی 5200319475328460053389 5200319475328460053389 Yes Dept. of Physiology and Pharmacology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان