fa اثر آدنین بر ترکیب شیمیایی سرم و اسمولالیته ادراری در موشهای نر تازه تولد یافته نژاد مقاله پژوهشی Original Research Article <div style="text-align: justify;"><span style="font-size:18px;"><span style="font-family:Times New Roman;"><strong><span style="color:#ffffff;"><span style="background-color:#16a085;">Background:</span></span></strong></span></span><span style="font-size:16px;"><span style="font-family:Times New Roman;"> Chronic renal failure leads to several functional disturbances in the regulation of body fluid composition, excretion, and metabolism which is known as uremic syndrome. There are reports of chronic renal disturbances following adenine containing food regimens in animals. In this study, the effect of intraperitoneal injection of soluble adenine on chemical composition of serum and urine osmolality was investigated.</span></span><br> <span style="font-size:18px;"><span style="font-family:Times New Roman;"><strong><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods: </span></span></strong></span></span><span style="font-size:16px;"><span style="font-family:Times New Roman;">In this experimental study different concentrations of soluble adenine were injected to Sprague-Dawly rats from days 2 to 16 after birth. Factors such as serum and urine osmolality, urine volume and serum chemical factors such as glucose, urea, creatinine, sodium, potassium and body weight were measured after the injection of adenine up to 140 days.</span></span><br> <span style="color:#ffffff;"><span style="font-size:18px;"><span style="font-family:Times New Roman;"><strong><span style="background-color:#16a085;">Results:</span></strong></span></span></span><span style="font-size:16px;"><span style="font-family:Times New Roman;"> Serum osmolality, urea and creatinine increased after adenine injections, while body weight, urine osmolality and urine volume decreased. Meanwhile, the concentration of serum glucose, sodium and potassium did not show any significant changes.</span></span><br> <span style="font-size:18px;"><span style="font-family:Times New Roman;"><strong><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion: </span></span></strong></span></span><span style="font-size:16px;"><span style="font-family:Times New Roman;">Adenine induces an imbalance in many chemical factors of serum in chronic renal failure. Further studies on the effect of adenine reduction in diet on uremic syndrome are recommended.</span></span></div> 12 16 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-166&slc_lang=fa&sid=1 Habibollah Johari حبیب اله جوهری 5200319475328460069891 5200319475328460069891 Yes Shahrbano Oryan شهربانو عریان 5200319475328460069892 5200319475328460069892 No Kazem Parivar کاظم پریور 5200319475328460069893 5200319475328460069893 No Ali Haeri Rouhani علی حائری روحانی 5200319475328460069894 5200319475328460069894 No Nader Tanide نادر تنیده 5200319475328460069895 5200319475328460069895 No