fa ارزیابی تاثیر درمانی مکمل دارویی حصا-آ(HESA-A) همراه با آتورواستاتین بر روی کبد چرب غیر الکلی در موش صحرایی کارآزمایی بالینی Clinical Trials <p><strong><em>Background and Objective: </em></strong>Fatty liver disease occurs due to disturbances in lipid metabolism (increased fat synthesis and halting of catabolism) which eventually leads to the accumulation of large amounts of fat (triglycerides) in liver cells, that if left untreated lead to inflammation and cirrhosis. This study aimed to investigate the effect of concomitant use of HESA-A and atorvastatin on biochemical parameters in non-alcoholic fatty liver disease compared with atorvastatin alone.</p> <p><strong><em>Methods and </em></strong><strong><em>Materials</em></strong><strong><em>:</em></strong> 28 rats weighing 180&plusmn;20 g were randomly divided into two groups: a control group (n = 7) with standard diet and a HFD (high-fat diet) group (n=21) which were fed for 8 weeks. To confirm the induction of fatty liver; controls along with seven rats from the HFD group were killed. The remaining 14 animals were divided into two groups. The first group received atorvastatin and the second group received HESA-A in combination with atorvastatin daily for 30 days. Finally, biochemical parameters (glucose, lipid profile and liver enzymes) were measured and histological studies were performed on the liver samples.</p> <p><strong><em>Results: </em></strong>Biochemical parameters in the HESA-A combined with atorvastatin group were significantly decreased in comparison to the atorvastatin group (p<0.01). The histopathological study of liver tissue showed a significant reduction in the amount of fat tissue and conversion of fatty liver from grade ІІІ to grade І.</p> <p><strong><em>Conclusion:</em></strong> According to the results of this study, the use of HESA-A as a complementary treatment for fatty liver disease without side effects can be integral role in reducing the incidence of non-alcoholic fatty liver disease, especially in severe cases.</p> <p></p><p></p> Keywords: high-fat diet, Non-alcoholic fatty liver, HESA-A, Atorvastatin, Lipid profile, Liver enzymes 58 70 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1012&slc_lang=fa&sid=1 Majid Efati مجید عفتی 5200319475328460053329 5200319475328460053329 No Dept of Clinical Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran دانشگاه علوم پزشکی بقیه الله تهران Mahmoud Khorrami محمود خرمی 5200319475328460053330 5200319475328460053330 No Dept of Clinical Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran دانشگاه علوم پزشکی بقیه الله تهران Ali Zarei Mahmoud Abadi علی زارعی محمودی آبادی alizaremah2015@gmail.com 5200319475328460053331 5200319475328460053331 Yes Dept of Clinical Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran دانشگاه علوم پزشکی بقیه الله تهران Javad Raouf Sarshoori جواد رئوف سر شوری 5200319475328460053332 5200319475328460053332 No Dept. of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran دانشگاه علوم پزشکی بقیه الله تهران