fa بررسی اثر دگزامتازون در شیر خواران مبتلا به برونشیولیت حاد-کار آزمایی بالینی مقاله پژوهشی Original Research Article <p style="margin-left: 1.3pt; text-align: justify;"><strong><em>Background and Objective:</em></strong> Acute bronchiolitis during infancy is the most common cause of respiratory tract infections. The purpose of this study was to evaluate the effects of a single intramuscular injection of dexamethasone on infants less than 2 years old suffering from acute bronchiolitis.</p> <p style="text-align: justify;"><strong><em>Materials and Methods:</em></strong> In this double blind randomized clinical trial, sampling was random and from available patients. Eighty infants under 2 years of age were admitted to the Mohammad Kermanshahi hospital. With the first episode of wheezing in the emergency department, bronchiolitis was diagnosed. The patients were randomly divided into 2 groups, a drug group (1mg/kg dexamethasone) and a placebo group. The primary outcome was RDAI score, 4 hours after arrival and the secondary outcome was RDAI score, 7 days after arrival.</p> <p style="text-align: justify;"><strong><em>Results:</em></strong> A difference in the average of RDAI score at the time of arrival in the dexamethasone group<br> (4 &plusmn;1.49) versus placebo group (4.29 &plusmn;1.4) was not statistically significant. The mean RDAI score 4 hours after arrival in the dexamethasone group was 1.7&plusmn;1.2, while in the placebo group it was 3.66&plusmn;1.07. Mean RDAI score 7 days after arrival in the dexamethasone group was 0.5&plusmn;0.4 while in the placebo group it was 0.85&plusmn;0.71 which is significant.</p> <p style="text-align: justify;"><strong><em>Conclusion:</em></strong> Based on these results, it seems that a single dose of intramuscular dexamethasone in infants with acute bronchiolitis was effective in reducing RDAI score 4 hours and 7 days after arrival.</p> <p></p><p></p> Keywords: Dexamethasone, Bronchiolitis, RDAI score, Infant 1 9 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1031&slc_lang=fa&sid=1 Simin Gheini سیمین قینی simingheini@yahoo.com 5200319475328460053162 5200319475328460053162 Yes Dept.of Pediatrics, Faculty of Medicine, Kermanshh University of Medical Sciences, Kermanshah, Iran دانشگاه علوم پزشکی کرمانشاه، کرمانشاه Sareh Farshadfar ساره فرشادفر 5200319475328460053163 5200319475328460053163 No Dept.of Pediatrics, Faculty of Medicine, Kermanshh University of Medical Sciences, Kermanshah, Iran دانشکده‌ی پزشکی، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه Jamal Hoseini جمال حسینی 5200319475328460053164 5200319475328460053164 No Dept. of Biostatistics & Epidemiology, Faculty of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. دانشکده‌ی بهداشت، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه