fa بررسی پلی‌مورفیسم‌های A/C592- و A /G1082- ناحیه پروموتر ژن اینترلوکین 10 در افراد مبتلا به دیابت نوع دو در شمال غرب ایران کارآزمایی بالینی Clinical Trials <p style="text-align: justify;"><strong><em>Background and Objective</em></strong><strong><em>:</em></strong> Today diabetes is one of the most prevalent noncontagious diseases around the world. There is strong evidence showing inflammatory reactions play a crucial role in initiating this disease. Interleukin 10 is one of the most significant anti-inflammatory cytokines. Thus the present study was conducted to investigate the relationship between Interleukin 10 gene polymorphisms -592 A/C and -1082 A/G and susceptibility to type 2 diabetes patients<strong> (</strong>T2D).</p> <p style="text-align: justify;"><strong><em>Materials and Methods: </em></strong>In this study 75 T2D patients and 75 healthy controls were selected. DNA extraction was carried out and then the genotype in the -592 A/C and -1082A/G positions were determined using PCR-RFLP while chi squared (X²) was used as the statistical method for data analysis.</p> <p style="text-align: justify;"><strong><em>Results:</em></strong> The frequency of genotype AC and CC in the -592A/C position was significantly higher in type 2 diabetes patients compared to healthy controls (p<0.05).</p> <p style="text-align: justify;"><strong><em>Conclusions: </em></strong>The high frequency of C allele in -592A/C can be considered as a predisposing factor for type 2 diabetes.</p> <p></p><p></p> Key words: Type 2 diabetes, Polymorphism, Interleukin 10 99 107 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1038&slc_lang=fa&sid=1 Farzin Ferdousi فرزین فردوسی 5200319475328460053199 5200319475328460053199 Yes Genetic, Biology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran دانشگاه آزاد اسلامی، زنجان Amir Hossein Taromchi امیر حسین تارمچی taromchi@zums.ac.ir 5200319475328460053200 5200319475328460053200 No Dept. of Biotechnology and Nanotechnology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran دانشکده‌ی پزشکی، دانشگاه علوم پزشکی زنجان، زنجان Abdolreza Esmaeilzadeh عبدالرضا اسماعیل‌زاده 5200319475328460053201 5200319475328460053201 No Dept. of Immunology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran مرکز تحقیقات بیمارهای متابولیک، دانشگاه علوم پزشکی زنجان، زنجان