fa اثرات درمانی پوست میوه بلوط بر بهبود زخم سوختگی درجه 2 در مدل حیوانی کارآزمایی بالینی Clinical Trials <div style="text-align: justify;"><strong><em>Background and Objective: </em></strong>Second-degree burns are associated with several complications such as infection, septicemia, and unpleasant skin appearance and are one of the main causes of in-hospital mortality. Therefore, this study was designed to determine the therapeutic effects of <em>Q</em>.<em> persica </em>fruit skin on the healing of second-degree burn wounds.<br> <strong><em>Materials and Methods:</em></strong> In this experimental study, 60 mice were randomly assigned into three groups. Vaseline was used for group 1, 1% Silver <em>sulfadiazine</em> (SSD) cream was used for group 2, and Vaseline-based <em>Quercus persica L.</em> hydroalcoholic extract was used for group 3. After the development of second-degree burns with a pathologist&rsquo;s confirmation, the wound area was measured for a month by AutoCAD software. The wound was pathologically examined and data were analyzed by repeated measures ANOVA and Kruskal-Wallis using SPSS 18.<br> <strong><em>Results: </em></strong>Decrease in wound area was 72.01% in the <em>Quercus persica L</em>. group, 65.95% in the SSD group, and 59.12% in the Vaseline group. Mean wound recovery was higher in the <em>Q</em>.<em> persica </em>fruit skin group but not significant (<em>P>0.05)</em>. The mean number of wound hair follicles and sebaceous glands and mean wound angiogenesis were higher while wound inflammation intensity was lower in <em>Quercus persica L</em> group, but no significant difference in these variables was seen between the <em>Quercus persica L</em> and SSD groups (P>0.05).<br> <strong><em>Conclusion: </em></strong><em>Quercus persica L.</em> had relatively acceptable therapeutic effects on the healing of second-degree burn wounds compared to SSD and Vaseline.<br> &nbsp;<br> &nbsp;</div> Keywords: Quercus persica L, Burn, Silver Sulfadiazine, Quercus persica L. fruit skin 79 90 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1049&slc_lang=fa&sid=1 Gholamreza Shabanian غلامرضا شبانیان 5200319475328460053137 5200319475328460053137 Yes Dept. of Anesthesia, Shahrekord University of Medical Sciences, Shahrekord, Iran دانشگاه علوم پزشکی شهرکرد Saeid Heidari-Soureshjani سعید حیدری سورشجانی 5200319475328460053138 5200319475328460053138 No Dept. of Research and Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran دانشگاه علوم پزشکی شهرکرد Mahmoud Rafieian-Kopaei محمود رفیعیان 5200319475328460053139 5200319475328460053139 No Dept. of Pharmacology & Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran دانشگاه علوم پزشکی شهرکرد Mitra Saadat میترا سعادت 5200319475328460053140 5200319475328460053140 No Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran دانشگاه علوم پزشکی شهرکرد Mohammadreza Shabanian محمدرضا شبانیان shabanian.mohammadreza@gmail.com 5200319475328460053141 5200319475328460053141 No School of Medicine , Isfahan University of Medical Sciences, Isfahan, Iran دانشگاه علوم پزشکی شهرکرد