Journal of Advances in Medical and Biomedical Research

fa تهیه و بررسی اثرات ضد باکتریایی و ضد قارچی مشتقات جدید ایزاتین و ایندول واجد استخلاف هیدانتوئین Preparation and Evaluation of Antibacterial and Antifungal Effects of Novel Isatin and Indole Derivatives Bearing a Hydantoin Moiety کارآزمایی بالینی Clinical Trials Background and Objective: Bacterial infections are an important and growing problem across the world. During the last few decades, the inappropriate consumption of antibiotics has led to increased antimicrobial resistance. A survey of literature demonstrates that isatin and indole rings are among the most favorable compounds with a potential for antimicrobial activity. Therefore in this study some novel isatin and indole derivatives coupled with hydantoin moiety were synthesized using a hybridization approach in order to evaluate the relationship between structure and antibacterial/antifungal activity. Materials and Methods: The derivatives were prepared in good yields and their structures were confirmed using H-NMR, IR, and Mass Spectrometry. The antibacterial/antifungal activity of compounds was evaluated using the Broth Microdilution method on a series of gram positive and gram negative bacterial strains and Aspergillus niger. Results: Among the tested compounds, the indole derivative #5 exhibited the highest activity against Pseudomonas aeruginosa with a MIC value of 31.25 µg/mL. <a>Conclusion</a><a href="#_msocom_1" id="_anchor_1" name="_msoanchor_1">[vog1]</a> : These synthesized derivatives showed effective antibacterial activity mainly against Pseudomonas aeruginosa. On the other hand the tested compounds had appropriate spectrum effect ,because they showed antibacterial effect on both positive and negative strains. <div> <hr align="left" size="1" width="33%" > <div> <div id="_com_1"><a name="_msocom_1"></a> <a href="#_msoanchor_1">[vog1]</a> the English conclusion s the hould be written as Persian conclusion.</div> </div> </div> Keywords: Hydantoin, Antibacterial, Antifungal, Preparation 113 121 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1052&slc_lang=fa&sid=1 Shohre Mohebbi شهره محبی 5200319475328460053155 5200319475328460053155 Yes Dept. of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran دانشکده‌ی داروسازی ، دانشگاه علوم پزشکی زنجان، زنجان Maryam Hassan مریم حسن 5200319475328460053156 5200319475328460053156 No Dept. of Food and Drug Control, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran دانشکده‌ی داروسازی ، دانشگاه علوم پزشکی زنجان، زنجان Elaheh Gorji الهه گرجی 5200319475328460053157 5200319475328460053157 No Dept. of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran دانشکده‌ی داروسازی ، دانشگاه علوم پزشکی زنجان، زنجان