fa بررسی دارورسانی نانوذرات مزوحفره‌ی سیلیکایی – نانومیله طلا و تاثیر کورکومین درون این نانوذرات برروی رده‌های سلول MCF7 و 4T1 سرطان سینه کارآزمایی بالینی Clinical Trials <strong><em>Background and Objective:</em></strong> Curcumin is a polyphenolic anti-cancer and anti-inflammatory agent and can be used both orally and by injection. In this study, nanoparticles of silica mesopore- gold nano were synthesized as a new drug delivery system. For this aim, gold nanoparticles as a promising system for effective drug delivery of curcumin was used and nano gold were delivered to breast cancer cells .<br> <strong><em>Materials and Methods:</em></strong> The synthetic nanoparticles characteristics were determined with different techniques such as transmission electron microscopy (TEM), nitrogen gas desorption, absorption analysis and dynamic light scattering techniques (DLS). The anti-cancer effects of this system were evaluated in cell culture, using MTT cytotoxicity test. The efficiency of this system was tested on human breast cancer (MCF-7) and 4T1 cell lines.<br> <strong><em>Results:</em></strong> The mean size of nano system was less than 30 nm, similar to the data obtained from Dynamic light scattering technique. The amount of curcumin loading in nano- system was about 80 percent. Isotherm - nitrogen adsorption AuNR@msio2 and CUR @ AuNR @ msio2 show that specific area of nano-Au @ msio2 was about -1834 m²g but by creating medication this particular area decrease to 234 m²g^-1. IC50 for curcumin loaded mesoporous silica nanoparticles for MCF-7 at the time of 48 hours and 4T1 were 19.5 and 14.6 micro molar respectively. The survival rate of the cells after treatment with different concentrations did not change considerably in the nano structures which demonstrate the lack of toxicity of nanoparticles.<br> <strong><em>Conclusion:</em></strong> The nanoparticle caused apoptosis in breast cancer cells more than free drug.<br> &nbsp;<br> &nbsp; Keywords: Curcumin, Gold, Breast cancer, Drug delivery systems, Cell toxicity test 122 134 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1053&slc_lang=fa&sid=1 Hossein Danafar حسین دانافر 5200319475328460053158 5200319475328460053158 Yes Dept, of Medicinal Chemistry, School of Pharmacy Zanjan University of Medical Sciences Zanjan, Iran دانشکده‌ی داروسازی، دانشگاه علوم پزشکی زنجان Hamid Reza Kheiri Manjili حمیدرضا خیری منجیلی h.kheiri@zums.ac.ir 5200319475328460053159 5200319475328460053159 No Dept. of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran دانشکده‌ی داروسازی، دانشگاه علوم پزشکی زنجان Elaheh Attari الهه عطاری 5200319475328460053160 5200319475328460053160 No Student Researches Committee, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran دانشکده‌ی داروسازی، دانشگاه علوم پزشکی زنجان Ali Sharafi علی شرفی 5200319475328460053161 5200319475328460053161 No Dept. of Biotechnology, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran دانشکده‌ی داروسازی، دانشگاه علوم پزشکی زنجان