en تأثیر Foeniculum vulgare (رازیانه) بر زمان بندی بلوغ، عملکرد تولیدمثل و رفتار در موش های ماده بالغ در معرض آن از نوزادانی Medical Laboratory and Animal Investigation Medical Laboratory and Animal Investigation مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-family:times new roman;"><span style="font-size:14px;"><strong><span style="color:#008080;">Background & Objective:</span></strong><span style="color:#008080;"> </span>Fennel, as an edible plant, and due to its estrogenic compounds, has widely been used as a therapeutic agent for centuries. In this study, the effects of neonatal exposure to fennel alcoholic extract (FAE), on the onset of puberty, estrus cycle, ovaries, and lordosis were investigated.<br> <span style="color:#008080;"><strong>Materials & Methods:</strong> </span>In this experimental study, 48 female BALB/c pups were divided into 4 groups: control (without treatment), treatment with estradiol benzoate (EB), 100 and 200 (mg/kg bw) FAE that were daily administered for 5 days from birth.<span dir="RTL"></span><br> <span style="color:#008080;"><strong>Results: </strong></span>The age at vaginal opening (VO) was significantly earlier in EB and 200 FAE. Body weight at VO was lower than control only in EB. A disrupted estrus cycle, decreased number of cycles and increased index diestrus were observed in EB and 200 FAE treated mice. Ovary weight in the EB-, 100- and 200 FAE-treated groups were lower. The number of Graafian follicles in the EB-, 100- and 200 FAE and number of corpus luteum in the EB and 200 FAE groups were lower than that of control females. Estradiol concentration increased in the EB and 200 FAE and LH concentration decreased in the EB-, 100- and 200 FAE groups. The lordosis quotient (LQ) was significantly low in the EB- and 200 FAE-treated groups, vis-&agrave;-vis the control group.<br> <span style="color:#008080;"><strong>Conclusion: </strong></span>The present results indicated that neonatal exposure to FAE induces early VO and disrupts ovary function. In addition, fennel acts like <em>xenoestrogens</em>&nbsp;and causes defeminization of the brain in the estrus cycle as well as lordosis in mice.</span></span></p> Foeniculumvulgare, Puberty, Reproductive Health, Lordosis 16 22 http://journal.zums.ac.ir/browse.php?a_code=A-10-329-5&slc_lang=en&sid=1 Rahmatollah Parandin رحمت الله پرندین rahmatparandin@pnu.ac.ir 5200319475328460047227 5200319475328460047227 Yes Dept. of Biology, Faculty of Sciences, Payame Noor University, Iran Namdar Yousofvand نامدار یوسف‌وند rparandin@gmail.com 5200319475328460047228 5200319475328460047228 No Dept. of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran