en بررسی عوامل پیش آگهی مرگ و میر در بیماران مبتلا به انسداد مزمن ریه Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p class="MsoNormal" style="text-align:justify;line-height:normal"><span style="color:#008080;"><strong>Background and Objective: </strong></span>Chronic Obstructive Pulmonary Disease (COPD) is a chronic obstructive and irreversible disease which has a high mortality and morbidity rate. Systemic inflammation and the thrombotic process can influence the prognosis of these patients. The objectives of this study were to evaluate prognostic effects of CBC indices (WBC, PMN, MPV, RDW), forced expiratory volume-one second (FEV1) and mean Pulmonary Artery Pressure (mPAP) in the prognosis of COPD patients with acute exacerbation of the disease.<br> <span style="color:#008080;"><strong>Material and Methods</strong>: </span>This cross-sectional study was performed on exacerbated COPD patients who were admitted to the emergency department, Afzalipour Hospital, Kerman, Iran during 2016-2017. For all the patients, CBC was assessed as they arrived then Pulmonary Function Test and echocardiography were conducted.&nbsp; In order to create the final model, we employed multivariate regression analysis.<br> <span style="color:#008080;"><strong>Results:</strong></span> A total of 1078 patients were enrolled during one year, of which 58.3% were male. In multivariate analysis, White blood cells (WBC), Polymorphonuclear leukocytes (PMN), Mean platelet volume (MPV), Red Cell Distribution Width (RDW), FEV1 and mPAP were the six variables which are independently associated with hospital mortality and ICU admission. Sensitivity, specificity and area under the curve for these six variables model were 78.5, 92 and 86% respectively.<br> <span style="color:#008080;"><strong>Conclusion: </strong></span>Since the inflammatory and thrombotic events are influential in the prognosis of COPD patients, it may be possible to predict patients outcome with CBC related indices (WBC, PMN, MPV and RDW), although other important risk factors such as pulmonary hypertension and FEV1 decrease should be considered as well.</p> COPD, Mean platelet volume, Red Cell Distribution Width, Hospital mortality 28 33 http://journal.zums.ac.ir/browse.php?a_code=A-10-4231-1&slc_lang=en&sid=1 Mehdi Torabi مهدی ترابی mtorabi1390@yahoo.com 5200319475328460047287 5200319475328460047287 Yes Dept. of Emergency Medicine, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran Mitra Samareh Fekri میترا ثمره فکری 5200319475328460047288 5200319475328460047288 No Pulmonology Cardiovascular Research Center, Institute of Basic and clinical physiology sciences, Kerman University of Medical Sciences, Kerman, Iran Sara Azizi Shoul سارا عزیزی شول 5200319475328460047289 5200319475328460047289 No Dept. of Emergency Medicine, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran Ahmad Naghibzadeh Thahami احمد نقیب زاده 5200319475328460047290 5200319475328460047290 No Dept. Epidemiology, Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Shiva Moeinaddini شیوا معین الدینی 5200319475328460047291 5200319475328460047291 No Dept. of Emergency Medicine, Faculty of Medicine, Rafsanjan University of Medical Sciences, Kerman, Iran