fa بررسی اثرات محافظتی پودر سیر بر عملکرد قلب هایپرتروفی شده ناشی از تستوسترون در موش صحرایی کارآزمایی بالینی Clinical Trials <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span style="color:#008080;"><strong><em>Background and Objective</em></strong>:</span> The androgens cause the cardiac hypertrophy and cardiomyopathy. There are reports of garlic protective effects in the cardiac hypertrophy due to overload and catecholamine. The aim of this study was to investigate the effects of garlic powder on testosterone-induced cardiac hypertrophy in rats.<br> <span style="color:#008080;"><strong><em>Materials and Methods</em></strong>:</span> This experimental study was performed on Wistar male rats in 5 groups (n = 8-7) including the testosterone group (10 mg testosterone enanthate for 20 days), the garlic group (1.6 g for 10 days) Day), the control garlic group and finally the garlic + testosterone. The separated hearts were perfused according to Langendorff method and passed three basal stages, ischemia and reperfusion. The structural and functional parameters of left ventricular fluctuations (LVDP), ventricular contractility (dp / dt) and (RPP) were measured.<br> <span style="color:#008080;"><strong><em>Results</em></strong><em>:</em></span> In the testosterone-induced hypertrophy group, the cardiac weight, the thickness of the left ventricular wall and the functional parameters of the heart, such as LVDP, RPP, + dp / dt, and -dp / dt indicated significant increase. The use of garlic powder in the base period led to a significant decrease in these parameters (P <0.05). However, in the period of ischemic reperfusion, the effect was not significant.<br> <span style="color:#008080;"><strong><em>Conclusion</em></strong><em>:</em></span> The results showed that the garlic powder modifies the cardiac hypertrophy induced by testosterone administration in rats. In other words, the use of garlic powder could potentially reduce the severity of cardiac hypertrophy in rats, due to variations in functional and structural parameters.</span></span></p> Garlic, Cardiac Hypertrophy, Testosterone, Ischemia / Reperfusion, Rat 69 77 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1073&slc_lang=fa&sid=1 Dariush Shakibaei داریوش شکیبایی 5200319475328460051348 5200319475328460051348 No Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran دانشگاه علوم پزشکی کرمانشاه، کرمانشاه Ramin Gorgani رامین گرگانی 5200319475328460051349 5200319475328460051349 No Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran دانشگاه علوم پزشکی کرمانشاه، کرمانشاه Mahvash Hesari مهوش حصاری mahvashhesari@gmail.com 5200319475328460051350 5200319475328460051350 Yes Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran دانشگاه علوم پزشکی کرمانشاه، کرمانشاه Gholamreza Bahrami غلامرضا بهرامی 5200319475328460051351 5200319475328460051351 No Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran دانشگاه علوم پزشکی کرمانشاه، کرمانشاه Amir Kiani امیر کیانی 5200319475328460051352 5200319475328460051352 No Tissue Engineering and Regenerative Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran دانشگاه علوم پزشکی کرمانشاه، کرمانشاه