fa ﺑﺮرﺳﻲ اﺛﺮ داروی ﻓﻠﻮﻛﺴﺘﻴﻦ ﺑﺮ روی بافت تخمدان و اوویداکت در موش سوری ماده بالغ C/Balb کارآزمایی بالینی Clinical Trials <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span style="color:#008080;"><strong><em>Background and Objective</em></strong><strong>:</strong></span> Use of antidepressants such as fluoxetine, which is widely used worldwide and easily accessible to the public, causes complications such as temporary or permanent infertility. The present study was conducted to investigate the effects of fluoxetine on the ovaries and oviducts of mature female Balb/C mice.<br> <strong><em><span style="color:#008080;">Materials and Methods:</span> </em></strong>In this study after determining the appropriate dose of fluoxetine, it was injected intraperitoneally (IP) for 30 days into 75 adult Balb/C mice with doses of 15 mg/kg (group 1), 20 mg /kg (group 2), 25 mg /kg (group 3), control group (non-injection) and sham (distilled water injection). ANOVA analysis and Duncan test were used to compare the means with significant levels being considered (P<0.05) and (P <0.001).<br> <span style="color:#008080;"><strong><em>Results</em></strong>:</span> During macroscopic examination, significant ovary weight decrease was observed in all three doses<br> (P <0.001) and in microscopic studies, reduction of the small and large diameter, number of graph follicles and corpus luteum were observed (P <0.05 and P <0.001 respectively). Meanwhile, an increase in the number of degenerative follicles and damaged zona pellucidas was significant (P <0.001 and P <0.05), and oviduct diameter was significantly higher than the control group (P <0.05).<br> <span style="color:#008080;"><strong><em>Conclusion</em></strong>:</span> It can generally be concluded that fluoxetine has a damaging effect on ovarian and oviduct tissue of mice.</span></span></p> Fluoxetine, ovary, oviduct, follicle, mice 100 110 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1086&slc_lang=fa&sid=1 Mahsa Mansoriyan مهسا منصوریان 5200319475328460050982 5200319475328460050982 No Dept. of Biology, Karaj Branch, Islamic Azad University, Alborz, Iran کارشناس ارشد گروه زیست‌شناسی گرایش تکوین جانوری، دانشگاه آزاد اسلامی واحد کرج، کرج Parvin Torabzadeh Khorasani پروین تراب‌زاده خراسانی p.torabzadeh@gmail.com 5200319475328460050983 5200319475328460050983 Yes Dept. of Biology, Karaj Branch, Islamic Azad University, Alborz, Iran دکترای تخصصی زیست شناسی، استادیار گروه زیست‌شناسی گرایش تکوین جانوری، دانشگاه آزاد اسلامی واحد کرج ، کرج Mina Ramezani مینا رمضانی 5200319475328460050984 5200319475328460050984 No Dept.of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran دکترای تخصصی زیست شناسی ، دانشیار گروه زیست‌شناسی (تکوین جانوری)، دانشگاه آزاد اسلامی واحد تهران مرکزی ، تهران