fa تاثیر دوازده هفته تمرینات ورزشی ترکیبی (قدرتی، استقامتی، پیلاتس و PNF) بر سطوح فیبرین دی دایمر (FDD) و اینترلوکین-6 در بیماران زن مبتلا به مولتیپل اسکلروزیس با درجات مختلف ناتوانی مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span style="color:#008080;"><strong><em>Background and</em></strong><strong><em> Objective</em></strong>:</span> Multiple Sclerosis (MS) is a neurological disorder that can restrict individual&#39;s ability to carry on their activities. The aim of this study was to examine the effects of combined exercise training on serum Fibrin D-Dimer (FDD) and interleukin-6 in female multiple sclerosis patients with different levels of disability.<br> <span style="color:#008080;"><strong><em>Materials and Methods:</em></strong></span> 96 female patients with MS were selected and were divided into three groups based on their physical disability scale scores (EDSS): low disability (n=44), moderate disability (n=26) and severe disability (n=26). Afterwards, participants of each group were randomly divided into an experimental and a control group. Participants performed 12 weeks combined strength, endurance, Pilates and PNF training, three sessions per week, 45 to 60 minute for each session. Dependent and independent t-test was used to compare means between and within groups, respectively.<br> <strong><em><span style="color:#008080;">Results:</span> </em></strong>The results showed a significant decrease in fibrin D-dimer (p= 0.001) and interleukin-6 (p= 0.001) in the low disability group and interleukin-6 (p=0.004) in the severe disability group.<br> <strong><em><span style="color:#008080;">Conclusion:</span> </em></strong>It appears that performing combined exercise training results in a decrease in fibrin D-dimer, interleukin-6 and inflammation in low disability MS patients. Thus, these exercises are recommended as a complementary therapy alongside drug treatments for M.S patients.</span></span></p> Keywords: Multiple sclerosis, Combined training, Fibrin D-Dimer, Inter Lukin-6 35 47 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1089&slc_lang=fa&sid=1 Zahra Raisi زهرا رئیسی 5200319475328460050999 5200319475328460050999 Yes Dept. of Exercise Physiology, Shahrekord University, Shahrekord, Iran. کارشناس ارشد فیزیولوژی ورزشی، دانشگاه شهرکرد، شهرکرد Mihammad Faramarzi محمد فرامرزی 5200319475328460051000 5200319475328460051000 No Dept. of Exercise Physiology, Shahrekord University, Shahrekord, Iran. دکترای تخصصی فیزیولوژی ورزشی، دانشیار گروه تربیت بدنی و علوم ورزشی، دانشگاه شهرکرد، شهرکرد Ebrahim Banitalebi ابراهیم بنی طالبی 5200319475328460051001 5200319475328460051001 No Dept. of Exercise Physiology, Shahrekord University, Shahrekord, Iran. دکترای تخصصی فیزیولوژی ورزشی، استادیار گروه تربیت بدنی و علوم ورزشی دانشگاه شهرکرد، شهرکرد Masoumeh Samieyan معصومه سمیعیان 5200319475328460051002 5200319475328460051002 No Dept. of Exercise Physiology, Shahrekord University, Shahrekord, Iran. کارشناس ارشد فیزیولوژی ورزشی دانشگاه شهرکرد، شهرکرد