en تاثیر 8 هفته تمرین هوازی و عصاره سیاه دانه بر مقاومت انسولینی، پروفایل لیپیدی و سطح پلاسمائی HbAlc موش های صحرایی دیابتی نوع 2 Medical Laboratory and Animal Investigation Medical Laboratory and Animal Investigation مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#008080;"><strong>Background and Objective:</strong></span> Metabolic syndrome is defined as a cluster of metabolic disorders, which may lead to type II diabetes and cardiovascular diseases. The aim of this study was to investigate the effect of 8 weeks of aerobic training and Nigella sativa supplements on insulin resistance, lipid profiles, and plasma levels of HbA1c in Type 2 diabetic rats.<br> <span style="color:#008080;"><strong>Materials and Methods:</strong></span> 35 male Wistar rats were divided into five groups. Diabetes was induced by intraperitoneal injection of streptozotocin. The training program included 8 weeks of aerobic training on a treadmill. The supplement group consumed N. Sativa supplement at the end of each training session at the dose of 400mg/kg/day. After 8 weeks of aerobic training and N.Sativa consumption, the plasma levels of HbA1C, insulin resistance and lipid profiles were measured.<br> <span style="color:#008080;"><strong>Results:</strong> </span>The results showed that blood glucose level in all three groups was significantly lower than the baseline (P=0.0001). Cholesterol, triglyceride and LDL showed the most significant decrease in aerobic and combination training groups (P=0.0001). In HDL index, aerobic and combined exercise groups showed a significant increase (P=0.0001). Hemoglobin A1c index and insulin resistance in the combination group showed a significant decrease compared to the other groups (P=0.0001).<br> <span style="color:#008080;"><strong>Conclusion:</strong></span> The results show that exercise along with N. Sativa supplement is more effective than N. sativa supplement or exercise alone in the status of rats with type 2 diabetes. This kind of combination therapy may also be applicable to diabetic patients.</span></span></p> Diabetes, Aerobic Training, Nigella, Insulin resistance 20 29 http://journal.zums.ac.ir/browse.php?a_code=A-10-4418-1&slc_lang=en&sid=1 Solmaz Babaei bonab سولماز بابائی بناب s.babaei@maragheh.ac.ir 5200319475328460054452 5200319475328460054452 Yes Dept. of Sport Sciences,Faculty of Human Sciences, University of Maragheh, Maragheh, Iran asghar tofighi اصغر توفیقی a.tofighi@urmia.ac.ir 5200319475328460054453 5200319475328460054453 No Dept. of Physical Education and Sport Sciences, Faculty of Human Sciences, Urmia University, Urmia, Iran