en کاهش سمیت بیسفنول A در تخمدان موش ویستار با آلوئه ورا Medical Laboratory and Animal Investigation Medical Laboratory and Animal Investigation مقاله پژوهشی Original Research Article <div style="text-align: justify;"><span style="color:#008080;"><strong>Background & Objective:</strong></span> &nbsp;Bisphenol A (BPA) is a hazardous environmental pollutant, which is known to cause ovarian toxicity. The present study aimed to assess the protective effects of <em>Aloe vera</em> herbal extract against ovarian toxicity caused by BPA in Wistar rats.<br> <span style="color:#008080;"><strong>Materials & Methods:</strong></span> &nbsp;The sample population of this experimental study consisted of 40 adult female Wistar rats with a mean weight of 200&plusmn;20 grams. The test animals were investigated in five groups after synchronizing, including one control group and one vehicle group (olive oil 5 ml/kg b.wt./day). Rats in the experimental groups were administered with various oral doses of BPA and <em>Aloe</em> <em>vera</em> extract daily for eight consecutive weeks (400 mg <em>Aloe vera</em> gel/kg b.wt./day, 10 mg BPA/kg b.wt./day dissolved in 5 ml/kg of olive oil, and BPA + <em>Aloe vera</em>). Blood samples (2 ml) were obtained from anesthetized rats after the intervention in order to measure the levels of oxidative stress markers and sex hormones. Moreover, the researchers collected both ovaries for histological examinations.<br> <span style="color:#008080;"><strong>Results: </strong></span>&nbsp;BPA decreased estradiol levels significantly (<em>P</em><0.05). In addition, while thiol protein (G-SH) and total antioxidant capacity (TAC) decreased, malondialdehyde (MDA) showed an increase. Fewer corpus luteum and antral follicles, more atretic follicles and several cysts were observed in histopathological results of BPA group. But total antioxidant capacity and ovarian tissue healing structure were accelerated by co-administration of Aloe vera with BPA.<br> <span style="color:#008080;"><strong>Conclusion: </strong></span>&nbsp;According to the results, the use of herbal extract of <em>Aloe vera</em> could significantly inhibit the debilitating effects of BPA on the reproduction of female rats. Moreover, Aloe Vera gel exerted protective effects against folliculogenesis, stimulating the production of hormones to prevent the toxicity caused by BPA.</div> <div style="text-align: justify;"></div> Aloe vera, Bisphenol A, Rats, Ovary 17 23 http://journal.zums.ac.ir/browse.php?a_code=A-10-4479-1&slc_lang=en&sid=1 Mohammad Amin Behmanesh محمد امین بهمنش behmanesh.ma@yahoo.com 5200319475328460054172 5200319475328460054172 No Dept. of Histology, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran Mahsa Poormoosavi مهسا پورموسوی m.poormoosavi@ymail.com 5200319475328460054173 5200319475328460054173 Yes Research and Clinical Center for Infertility, Dezful University of Medical Sciences, Dezful, Iran Sima Jannati سیما جنتی sjanat@ymail.com 5200319475328460054174 5200319475328460054174 No Dept. of Obstetrics and Gynecology, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran Hosein Najafzadeh Varzi حسین نجف زاده ورزی najafzadehvarz@yahoo.com 5200319475328460054175 5200319475328460054175 No Dept. of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Ehsan Sangtarash احسان سنگ تراش ehsangtaras@gmail.com 5200319475328460054176 5200319475328460054176 No Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran