en تأثیر عصاره آبی زعفران و کروسین بر روی مدلهای موش PTSD: تمرکز بر یادگیری و حافظه مخصوص Medical Laboratory and Animal Investigation Medical Laboratory and Animal Investigation مقاله پژوهشی Original Research Article <div style="text-align: justify;"><span style="color:#008080;"><strong>Background & Objective:</strong></span> &nbsp;Post traumatic stress disorder (PTSD) is an anxiety reaction, which occurs as a result of encountering a seriously traumatic event during one&rsquo;s lifetime. The aim of this study was to evaluate the effect of saffron aqueous extract and crocin on spatial memory and learning with the Barnes maze in a PTSD model on male Wistar rats (Weighting 200&ndash;250 gr).<br> <span style="color:#008080;"><strong>Materials & Methods:</strong></span> &nbsp;Wistar rats (n=48) were randomly divided into two groups: PTSD and non-PTSD. The PTSD group first received intra-cerebero-ventricular (ICV) administration of 10 &micro;g/rat aqueous saffron extract, crocin or saline and then an electric foot shock. After 21 days, both groups were returned to the electric shock box in order to remember stressors without receiving any shocks. Corticosterone levels were then measured in the samples. Concurrently, a digital camera was recording the animals&rsquo; behaviors. Upon this, spatial learning and memory was assessed for five consecutive days.<br> <strong>&nbsp;<span style="color:#008080;">Results: </span></strong>&nbsp;The saffron extract and crocin caused a significant increase (<em>P</em><0.001) in corticosterone levels and a significant reduction (<em>P</em><0.05) in freezing behavior, as well as a significant difference (<em>P</em><0.001) in spatial learning of the two groups.<br> <span style="color:#008080;"><strong>Conclusion: </strong></span>&nbsp;Our results indicate the potential role of saffron aqueous extract and its active derivative (crocin) in improving behavioral symptoms and spatial learning in PTSD models.</div> Traumatic stress disorder,Crocin,Corticosterone,Spatial learning,Spatial memory, 34 42 http://journal.zums.ac.ir/browse.php?a_code=A-10-4496-1&slc_lang=en&sid=1 Sara Asalgoo سارا علسگو asalgosara@yahoo.com 5200319475328460047265 5200319475328460047265 No Behavioral Sciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Behavioral Sciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Gila Pirzad Jahromi ژیلا پیرزاد جهرمی gpirzad1340@gmail.com 5200319475328460047266 5200319475328460047266 Yes Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran Boshra Hatef بشرا هاتف boshrahatef@yahoo.com 5200319475328460047267 5200319475328460047267 No Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran Hedayat Sahraei هدایت صحرایی hsahraei1343@gmail.com 5200319475328460047268 5200319475328460047268 No Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran