en تأثیر سلول‌های بنیادی مزانشیمی مشتق از مغز استخوان بر بقای فلپ تصادفی پوست در موش‌های دیابتی شده با استرپتوزوتوسین Medical Laboratory and Animal Investigation Medical Laboratory and Animal Investigation مقاله پژوهشی Original Research Article <div style="text-align: justify;"><span style="color:#008080;"><strong>Background & Objective:</strong> </span>&nbsp;Wound dressing and healing in diabetic patients is encountered with many problems. This study aims to investigate the effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on the survival of random skin flap (RSF) on Streptozotocin-induced diabetic rats (STZ) using an optical microscope.<br> <span style="color:#008080;"><strong>Materials & Methods:</strong> </span>&nbsp;In this study, 60 male Albino Wistar rats were used (<em>average weight </em>250-300 gr). The rats were divided into six groups: 1). Health-Non (HN), 2). Health- Cells (HC), 3). Health &ndash;Sham (HS), 4). Diabetic-Non (DN) that were became diabetic by injecting STZ 70 mg/kg intraperitoneally), 5). Diabetic-Sham (DS), 6). And Diabetic-Cell (DC). In all groups, the day of surgery was considered as the zero day, on the back area of animal, the flap was created with a size of 8 &times; 3 cm and the BM-MSCs were performed. The sampling was performed on day 7 after surgery from the region where Transitional Zone (TZ) necrosis was initiated.<br> <span style="color:#008080;"><strong>Results: </strong></span>&nbsp;BM-MSCs increased the number of blood vessels (<em>P</em><span dir="RTL">=</span>0.009) and the histology parameters (wound demarcation <em>P</em>=0.0001, granulation tissue <em>P</em>=0.0001) significantly compared to the control group. But this increase was not significant in the area of the survival region.<br> <span style="color:#008080;"><strong>Conclusion: </strong></span>&nbsp;It was concluded that after treatment with BM-MSCs, the wound healing process in both non-diabetic and diabetic groups was increased in accordance with histological characteristics.</div> Diabetes mellitus, Random skin flap, Bone marrow, Stem cells, Streptozotocin, Survival 24 33 http://journal.zums.ac.ir/browse.php?a_code=A-10-4499-1&slc_lang=en&sid=1 Khadijah Rezazadeh خدیجه رضازاده khadijeh.rezazadeh1975@gmail.com 5200319475328460054177 5200319475328460054177 No Student Research Committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Farzaneh Chehelcheraghi فرزانه چلچراغی chehelcheraghi.farzaneh@lums.ac.ir 5200319475328460054178 5200319475328460054178 Yes Dept. of Anatomical Sciences, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Khatereh Anbari خاطره عنبری dr.anbari@gmail.com 5200319475328460054179 5200319475328460054179 No Dept. of Social Medicine, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran