en تأثیر عصارۀ هیدروالکلی Biarum carduchrum بر استرس اکسیداتیو و کاتالپسی در مدل موش صحرایی 6 هیدروکسیدوپامین از بیماری پارکینسون Medical Laboratory and Animal Investigation Medical Laboratory and Animal Investigation مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-family:times new roman;"><span style="font-size:14px;"><strong><span style="color:#008080;">Background and Objective</span></strong><span style="color:#008080;">: </span>Parkinson is a neurodegenerative disease that leads to incurable and debilitating conditions. Herbal extracts can afford protection against neurodegenerative diseases due to their bioactive compounds. In the present study, we investigated the effect of hydro-alcoholic extract of <em>B. carduchrum </em>on catalepsy and brain oxidative stress in rat&rsquo;s model of Parkinson&rsquo;s disease.<br> <span style="color:#008080;"><strong>Materials and Methods: </strong></span>Rats were randomly divided into five groups of eight animals. The control group was left intact. Parkinsonian group received an injection of 6-hydroxydopamine (6-OHDA) in the right anterior mid-brain. Extract treated groups received hydro-alcoholic extract of <em>B. carduchrum </em>at doses of 100, 200 and 400mg/kg by gavage seven days after 6-OHDA injection. 14 days after treatment, bar test was performed and lipid peroxide levels of different brain regions were determined. Data were analyzed by ANOVA followed by Tukey&#39;s test using SPSS software and <em>P</em><0.05 was considered statistically significant.<br> <span style="color:#008080;"><strong>Results: </strong></span>In 6-OHDA-lesioned group, bar time was increased significantly (<em>P</em><0.05) when compared with the control group (122.50&plusmn;90.12 versus 0.00&plusmn;0.00).&nbsp;<em>B. carduchrum</em> at doses of 200 and 400mg/kg significantly reduced 6-OHDA induced catalepsy (<em>P</em><0.0.5). 6-OHDA treatment leads to significant increases in lipid peroxide levels of cerebellum, cortex, hippocampus and striatum (<em>P</em><0.05). Administration of <em>B. carduchrum </em>extract at different doses caused significant reduction in the lipid peroxide levels of different brain regions (<em>P</em><0.05).<br> <span style="color:#008080;"><strong>Conclusion: </strong></span><em>B. carduchrum </em>extract ameliorated 6-OHDA -induced catalepsy and lipid peroxide level of brain in rat&rsquo;s model of Parkinson&rsquo;s disease.</span></span></p> Biarum carduchrum, Catalepsy, Parkinson’s disease, Lipid peroxide 8 13 http://journal.zums.ac.ir/browse.php?a_code=A-10-563-7&slc_lang=en&sid=1 Mahbubeh Setorki محبوبه سترکی doctor.setorgi@gmail.com 5200319475328460054445 5200319475328460054445 No Dept. of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran دانشگاه ازاد Zahra Hooshmandi زهرا هوشمندی zhoushmandi@yahoo.com 5200319475328460054446 5200319475328460054446 No Dept. of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran دانشگاه ازاد Zahra Zanganehnejad زهرا زنگنه نزاد zzanganehnejad@yahoo.com 5200319475328460054447 5200319475328460054447 Yes Dept. of Biology, Shahrekord Branch, Islamic Azad University, shahrekord, Iran دانشگاه ازاد